{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T18:49:55Z","timestamp":1774723795317,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the changes of cervical soluble immune markers after focused ultrasound (FU) treatment to explore the underlying local immune effects of FU in the treatment of high\u2010risk human papillomavirus (HR\u2010HPV) infection\u2013related low\u2010grade squamous intraepithelial lesion (LSIL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 35 patients diagnosed with HR\u2010HPV infection\u2013related histological LSIL who met the inclusion criteria were enrolled in this prospective study and treated with FU. The authors used cytometric bead array to measure T\u2010helper type 1 (Th1) cytokine (interleukin [IL] 2, tumor necrosis factor, and interferon \u03b3) and Th2 cytokine (IL\u20104, IL\u20105, IL\u20106, and IL\u201010) levels in the cervicovaginal lavage of patients before and 3\u2009months after FU treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After FU treatment, the concentrations of Th2 cytokines IL\u20105 and IL\u20106 were significantly lower than those before FU treatment (<jats:italic>P<\/jats:italic>\u2009=\u20090.044 and <jats:italic>P<\/jats:italic>\u2009=\u20090.028, respectively). HR\u2010HPV infection was cleared in 27 patients, with a clearance rate of 77.1% (27 of 35). The concentration of IL\u20104 in patients with HR\u2010HPV clearance after FU treatment was significantly lower than that in patients without HR\u2010HPV clearance (<jats:italic>P<\/jats:italic>\u2009=\u20090.045).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>FU can inhibit the production of certain Th2 cytokines and may improve the local immune status of the cervix, thereby eliminating HR\u2010HPV infection.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14768","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T15:48:15Z","timestamp":1680536895000},"page":"983-988","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Changes in cervical cytokine profiles following focused ultrasound treatment for high\u2010risk human papillomavirus infection\u2013related low\u2010grade cervical 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