{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:05:27Z","timestamp":1785240327102,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the hemostatic effects of tranexamic acid (TXA) ex vivo in women with pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was an ex vivo study involving 45 normal pregnant women and 45 women with pre\u2010eclampsia (nine with mild and 36 with severe features) matched for age, gestational age, and body mass index. Blood samples were collected and divided into two parts. The first served as the pre\u2010TXA sample, while the second was spiked with TXA and served as the post\u2010TXA sample. Plasma levels of D\u2010dimer and plasmin\u2013antiplasmin complex (PAP) were determined using enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean D\u2010dimer and PAP values in the pre\u2010TXA samples differed significantly between groups. Following spiking with TXA, the mean D\u2010dimer and PAP levels did not differ significantly in the pre\u2010TXA and post\u2010TXA samples (<jats:italic>P<\/jats:italic>\u2009=\u20090.560 and <jats:italic>P<\/jats:italic>\u2009=\u20090.500, respectively) in the pre\u2010eclampsia cohort. In normal pregnancy, the mean D\u2010dimer and PAP levels in the post\u2010TXA samples did not differ significantly (<jats:italic>P<\/jats:italic>\u2009=\u20090.070 and <jats:italic>P<\/jats:italic>\u2009=\u20090.050, respectively) from the pre\u2010TXA samples following TXA spiking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TXA did not significantly affect D\u2010dimer and PAP levels in pre\u2010eclampsia, suggesting that TXA may not increase the thrombotic risks in patients with pre\u2010eclampsia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14779","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T11:15:23Z","timestamp":1681730123000},"page":"931-936","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluating the hemostatic effects of tranexamic acid in women with pre\u2010eclampsia"],"prefix":"10.1002","volume":"162","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4505-8217","authenticated-orcid":false,"given":"Helen C.","family":"Okoye","sequence":"first","affiliation":[{"name":"Department of Hematology and Immunology College of Medicine University of Nigeria Ituku\u2010Ozalla campus  Enugu Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha","family":"Othman","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Molecular Sciences, School of Medicine Queen's University  Kingston Ontario Canada"},{"name":"School of Baccalaureate Nursing St Lawrence College  Kingston Ontario Canada"},{"name":"Department of Clinical Pathology, School of Medicine Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa U.","family":"Nwagha","sequence":"additional","affiliation":[{"name":"Department of Hematology and Immunology College of Medicine University of Nigeria Ituku\u2010Ozalla campus  Enugu Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel N.","family":"Onwusulu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine Nnamdi Azikiwe University  Awka Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robinson C.","family":"Onoh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Alex Ekwueme Federal University Teaching Hospital Abakaliki  Ebonyi Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chibuike O.","family":"Chigbu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, College of Medicine University of Nigeria Ituku\u2010Ozalla Campus  Enugu Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2005.00204.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2011.545818"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03761106"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20150702"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(11)70020-2"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2004.08.004"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(97)02734-6"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.14280"},{"key":"e_1_2_10_10_1","first-page":"165","article-title":"Tranexamic acid: a therapeutic alternative in patients with HELLP syndrome","volume":"86","author":"Torre JIC","year":"2018","journal-title":"Gynecol Obstet Mex"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.accpm.2015.11.004"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc11374"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/000331979504600810"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003891"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2016-203854"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000789"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3233\/NPM-16139"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13348"},{"key":"e_1_2_10_19_1","doi-asserted-by":"crossref","unstructured":"DallakuK Shakur\u2010StillH BeaumontD et al.No effect of tranexamic acid ion platelet function and thrombin generation (ETAPIaT) in postpartum haemorrhage: a randomized placebo\u2010controlled trial [version 1; 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