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It is a heterogeneous condition characterized by multiple triggers, making it challenging to define a reference standard for its treatment. In this manuscript we selected all articles including the following key criteria: \u201cvulvodynia\u201d. The primary outcomes observed included the resolution of chronic pelvic pain, dyspareunia and sexual satisfaction, psychological well\u2010being, and overall quality of life. Most pharmacologic treatments require further evidence to be recommended. On the other hand, non\u2010pharmacologic approaches such as psychotherapy, physical therapy, and surgery have received stronger support. This review summarizes pros and cons of adopting available treatments. Multimodal approaches should be introduced to improve patient outcomes. Further investigations are warranted to improve patients' quality of life.<\/jats:p>","DOI":"10.1002\/ijgo.14815","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T12:19:58Z","timestamp":1683548398000},"page":"510-520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Vulvodynia: A practical guide in treatment strategies"],"prefix":"10.1002","volume":"163","author":[{"given":"Giusi","family":"Santangelo","sequence":"first","affiliation":[{"name":"Department of Gynecological, Obstetrical and Urological Sciences \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfilippo","family":"Ruggiero","sequence":"additional","affiliation":[{"name":"Department of Gynecological, Obstetrical and Urological Sciences \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Murina","sequence":"additional","affiliation":[{"name":"Lower Genital Tract Disease Unit, Obstetrics and Gynecology Department, V. 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