{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T16:48:42Z","timestamp":1761324522730,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T00:00:00Z","timestamp":1683936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Code 001"],"award-info":[{"award-number":["Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe and compare the annual success rates of medical treatment in the analyzed period and to evaluate the associated factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective study with 158 women with tubal pregnancy followed up over 17\u2009years. Statistical analysis was performed using the Cochran\u2010Armitage test, the \u03c7<jats:sup>2<\/jats:sup> test, Mann\u2013Whitney test, and multiple logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The success rate was 47.4%. There was a trend of significant change in the success rate of clinical treatment over time (Z\u2009=\u20092.01, <jats:italic>P<\/jats:italic>\u2009=\u20090.044); it was associated to undergoing treatment between 2012 and 2017 (<jats:italic>P<\/jats:italic>\u2009=\u20090.028), the absence of abdominal pain (<jats:italic>P<\/jats:italic>\u2009=\u20090.020), receiving a higher dose of methotrexate (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and less time hospitalized (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). In the final statistical model, we observed that receiving a higher dose of methotrexate (<jats:italic>P<\/jats:italic>\u2009=\u20090.025, odds ratio [OR] 1.03, 95% confidence interval [CI] 1.00\u20131.06), having a low serum \u03b2\u2010HCG concentration before treatment (<jats:italic>P<\/jats:italic>\u2009=\u20090.003, OR 0.87, 95% CI 0.79\u20130.95), and not having abdominal pain (<jats:italic>P<\/jats:italic>\u2009=\u20090.004, OR 4.26, 95% CI 1.61\u201311.28) were factors associated with a higher chance of successful clinical treatment for tubal pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A greater chance of success was observed among women undergoing clinical treatment from 2012 onwards, who used higher doses of methotrexate, were asymptomatic at admission, and had low concentrations of \u03b2\u2010hCG.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14835","type":"journal-article","created":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T07:14:07Z","timestamp":1683962047000},"page":"1091-1097","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Adaptation of a Brazilian university hospital to clinical treatment of ectopic pregnancy: Lessons learned over 17\u2009years"],"prefix":"10.1002","volume":"162","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4060-8515","authenticated-orcid":false,"given":"B\u00e1rbara V. 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