{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:44:42Z","timestamp":1790023482088,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"publisher","award":["DPG5780003"],"award-info":[{"award-number":["DPG5780003"]}],"id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the associations between depot medroxyprogesterone acetate (DMPA) and endometrial cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicenter case\u2013control study was conducted among tertiary hospitals in Thailand. Patients were women with endometrial cancer. Controls were women admitted for other conditions, matched for age within 5\u2009years of the patients' age. The controls had to have no abnormal vaginal bleeding, history of hysterectomy, or cancers of the other organs. A standardized questionnaire was used to gather information. Conditional logistic regression was applied to calculate adjusted odds ratio (aORs) and 95% confidence intervals (CIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During 2015 to 2021, 378 patients and 1134 controls were included. Ever use of DMPA was associated with a 70% decreased overall risk of endometrial cancer (aOR, 0.30 [95% CI, 0.21\u20130.42]). Endometrial cancer risk declined by 3% (aOR, 0.97 [95% CI, 0.96\u20130.98]) for every 3\u2009months of DMPA use. The magnitude of the decline in endometrial cancer risk did not vary appreciably by cancer subtypes (aOR, 0.26 [95% CI, 0.17\u20130.41] and 0.38 [95% CI, 0.22\u20130.65] for low\u2010grade and high\u2010grade tumors, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Depot medroxyprogesterone acetate use was inversely associated with endometrial cancer risk in a duration\u2010dependent manner. This association was independent of cancer subtype.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14846","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T08:58:52Z","timestamp":1684141132000},"page":"96-102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Depot medroxyprogesterone acetate and endometrial cancer: A multicenter case\u2013control study"],"prefix":"10.1002","volume":"163","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9544-9462","authenticated-orcid":false,"given":"Chumnan","family":"Kietpeerakool","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Khon Kaen University  Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chalong","family":"Cheewakriangkrai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwanon","family":"Rattanakanokchai","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Faculty of Public Health Khon Kaen University  Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daungporn","family":"Rattanalappaiboon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Maharat Nakhon Ratchasima Hospital  Nakhon Ratchasima Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitima","family":"Tiyayon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Rajavithi Hospital, College of Medicine Rangsit University  Pathum Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wadwilai","family":"Chalapati","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Udonthani Hospital  Udon Thani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thumwadee","family":"Tangsiriwattana","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Khon Kaen Hospital  Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siriwan","family":"Tangjitgamol","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital Navamindradhiraj University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilaiwan","family":"Kleebkaow","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Khon Kaen University  Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surapan","family":"Khunamornpong","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amornrat","family":"Temtanakitpaisan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Khon Kaen University  Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narisa","family":"Sribanditmongkhol","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pisake","family":"Lumbiganon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Khon Kaen University  Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-0316"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003089"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001182"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2012.03298.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-007-0497-z"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910490208"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181577511"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13866"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000154151.14516.f7"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.24"},{"key":"e_1_2_10_13_1","first-page":"370","article-title":"How to define obesity? Evidence\u2010based multiple action points for public awareness, screening, and treatment: an extension of Asian\u2010Pacific recommendations","volume":"17","author":"Pan WH","year":"2008","journal-title":"Asia Pac J Clin Nutr"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq006"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000686"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00212-0"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29229"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002057"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.2307\/2530705"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2016.12.010"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.00151"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318188d1ec"},{"key":"e_1_2_10_23_1","first-page":"95","article-title":"Effects of long\u2010term use of depo\u2010medroxyprogesterone acetate on lipid metabolism in Nepalese women","volume":"31","author":"Yadav BK","year":"2011","journal-title":"Korean J Lab Med"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2020.06.008"},{"key":"e_1_2_10_25_1","first-page":"751","article-title":"DMPA suppresses cell proliferation and enhances cell apoptosis of eutopic endometrium in women with endometriosis: a randomized controlled study","volume":"99","author":"Tingthanatikul Y","year":"2016","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.121"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.14846","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T11:02:47Z","timestamp":1739962967000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.14846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,15]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/ijgo.14846"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.14846","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,15]]},"assertion":[{"value":"2023-03-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}