{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T17:01:26Z","timestamp":1764349286645,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To our knowledge, this is the first reported case of synchronous ovarian and vulva (Bartholin gland) cancer. A postmenopausal woman presented with a complex multiloculated left adnexal mass and 2\u2010cm right Bartholin gland mass. CA 125 was 59\u2009IU\/mL. Computed tomography of chest, abdomen, and pelvis showed a very large (32\u2009\u00d7\u200913.5\u2009\u00d7\u200922.5\u2009cm) complex mass arising from the pelvis and extending to the level of the T12\/L1 disk space. A right Bartholin mass with suspicious right inguinal nodes was seen. Midline laparotomy, total abdominal hysterectomy, bilateral salpingo\u2010oophrectomy, infracolic omentectomy, pelvic peritoneal biopsies, and peritoneal washings were carried out. Wide local excision of the right Bartholin gland mass was carried out in the same setting. Histopathology came back as Stage 2B left ovarian clear\u2010cell carcinoma and synchronous right Bartholin gland adenoid cystic carcinoma with lymphovascular invasion, incompletely excised, staged at least FIGO Stage 1B. Following local multidisciplinary team discussion and positron emission tomography scan review, the local committee agreed to start three cycles of adjuvant chemotherapy then proceed with Bartholin gland scar re\u2010excision and bilateral groin lymph node dissection. After the three cycles, the groin lymph nodes came back as metastatic adenocarcinoma with overall morphologic and immunohistochemical features consistent with metastatic ovarian clear\u2010cell carcinoma. Postoperative adjuvant chemotherapy was given. Initial follow\u2010up period over 9\u2009months was uneventful.<\/jats:p>","DOI":"10.1002\/ijgo.14880","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T05:56:37Z","timestamp":1684907797000},"page":"744-746","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Synchronous ovarian and Bartholin gland carcinoma: Case report and review of literature"],"prefix":"10.1002","volume":"163","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9335-8890","authenticated-orcid":false,"given":"Sally S.","family":"El\u2010Tawab","sequence":"first","affiliation":[{"name":"Oxford Gynaecological Cancer Centre, Churchill Hospital Oxford University Hospitals Foundation Trust  Oxford UK"},{"name":"ElShatby Maternity University Hospital, Gynecology Oncology Center, Faculty of Medicine Alexandria University  Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3830-9532","authenticated-orcid":false,"given":"Sean","family":"Kehoe","sequence":"additional","affiliation":[{"name":"Oxford Gynaecological Cancer Centre, Churchill Hospital Oxford University Hospitals Foundation Trust  Oxford UK"},{"name":"Nuffield Department of Women's &amp; Reproductive Health The Women's Centre, John Radcliffe Hospital  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0782"},{"volume-title":"General Surgical Pathology and Therapeutics","year":"1879","author":"Billroth T","key":"e_1_2_7_3_1"},{"key":"e_1_2_7_4_1","first-page":"1358","article-title":"Multiple primary malignant tumors. A survey of the literature and a statistical study","volume":"16","author":"Warren S","year":"1932","journal-title":"Am J Cancer"},{"volume-title":"The 2007 Multiple Primary and Histology Coding Rules","year":"2007","author":"Johnson CH","key":"e_1_2_7_5_1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.8316"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000601)88:11<2584::AID-CNCR22>3.0.CO;2-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e3182518557"},{"issue":"9","key":"e_1_2_7_9_1","first-page":"1506","article-title":"Less impact of adjuvant chemotherapy for stage I clear cell carcinoma of the ovary: a retrospective Japan clear cell carcinoma study","volume":"20","author":"Takano M","year":"2010","journal-title":"Int J Gynecol Cancer"},{"key":"e_1_2_7_10_1","article-title":"Primary carcinoma of Bartholin's gland. A report of 24 patients","volume":"39","author":"Chamlian DL","year":"1972","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_11_1","unstructured":"National Cancer Institute.Cancer Stat Facts: Vulvar Cancer. Accessed on April 28 2017.https:\/\/seer.cancer.gov\/statfacts\/html\/vulva.html"},{"volume-title":"Pathologische Anatomie der weiblichen Sexualorgane","year":"1864","author":"Klob JM","key":"e_1_2_7_12_1"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5256876"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2006.09.010"},{"key":"e_1_2_7_15_1","first-page":"857","article-title":"Synchronous primary cancers of the female reproductive tract in Turkish women","volume":"12","author":"Eser S","year":"2011","journal-title":"Asian Pac J Cancer Prev"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08766-9"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2017-000172"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.25769"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000031744"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-021-05257-8.Epub"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30566-7"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2022.01.026"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.14880","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T07:28:34Z","timestamp":1722410914000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.14880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,23]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/ijgo.14880"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.14880","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"type":"print","value":"0020-7292"},{"type":"electronic","value":"1879-3479"}],"subject":[],"published":{"date-parts":[[2023,5,23]]},"assertion":[{"value":"2023-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}