{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:35:59Z","timestamp":1791225359776,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T00:00:00Z","timestamp":1685923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The proportion of neonatal early\u2010onset sepsis (EOS) by gram\u2010negative bacteria has increased. The authors examined bacterial distribution in the amniotic membrane cultures of women with peripartum fever (PPF) and related perinatal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study covered the period 2011 to 2019. The primary outcomes were <jats:italic>Enterobacteriaceae<\/jats:italic>\u2010positive birth culture rates in women with PPF and the trend of ampicillin resistance. Maternal and neonatal outcomes were compared between women with group B <jats:italic>Streptococcus<\/jats:italic> (GBS) and <jats:italic>Enterobacteriaceae<\/jats:italic>\u2010positive isolates. Bacterial distribution was also compared according to rupture of membrane (ROM) duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 621 women with PPF, the positive birth culture rate was 52%. Increasing prevalences of ampicillin\u2010resistant <jats:italic>Enterobacteriaceae<\/jats:italic> (81%) were noted. Positive birth cultures were associated with maternal bacteremia (<jats:italic>P<\/jats:italic>\u2009=\u20090.017) and neonatal EOS (<jats:italic>P<\/jats:italic>\u2009=\u20090.003). Prolonged ROM \u226518\u2009h was associated with increased risk for <jats:italic>Enterobacteriaceae<\/jats:italic>\u2010positive cultures, while intrapartum ampicillin and gentamicin were associated with lower risk. <jats:italic>Enterobacteriaceae\u2010<\/jats:italic>positive compared with GBS\u2010positive birth cultures were associated with adverse maternal and neonatal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Positive birth cultures were related to maternal bacteremia and neonatal sepsis. Adverse outcomes were more prevalent among women with <jats:italic>Enterobacteriaceae<\/jats:italic>\u2010positive versus GBS\u2010positive birth cultures. Prolonged ROM is a risk factor for <jats:italic>Enterobacteriaceae<\/jats:italic>\u2010positive birth cultures among women with PPF. Antibiotic prophylaxis treatment for prolonged ROM should be reconsidered.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14899","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T08:40:57Z","timestamp":1686127257000},"page":"956-964","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Time to reconsider antibiotic prophylaxis in women with prolonged rupture of membranes: The trend of <i>Enterobacteriaceae<\/i> in peripartum infections"],"prefix":"10.1002","volume":"163","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0131-3936","authenticated-orcid":false,"given":"Raneen","family":"Abu\u00a0Shqara","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Galilee Medical Center  Nahariya Israel"},{"name":"Azrieli Faculty of Medicine Bar Ilan University  Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Glikman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Galilee Medical Center  Nahariya Israel"},{"name":"Azrieli Faculty of Medicine Bar Ilan University  Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saher","family":"Jad","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Galilee Medical Center  Nahariya Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagai","family":"Rechnitzer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Galilee Medical Center  Nahariya Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lior","family":"Lowenstein","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Galilee Medical Center  Nahariya Israel"},{"name":"Azrieli Faculty of Medicine Bar Ilan University  Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2060-3234","authenticated-orcid":false,"given":"Maya","family":"Frank\u00a0Wolf","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Galilee Medical Center  Nahariya Israel"},{"name":"Azrieli Faculty of Medicine Bar Ilan University  Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03574.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/649018"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200001063420103"},{"issue":"4","key":"e_1_2_10_5_1","first-page":"604","article-title":"The epidemiology of group B streptococcal colonization in pregnancy. 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