{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:14:49Z","timestamp":1791292489543,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T00:00:00Z","timestamp":1685664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005918","name":"Christian Medical College, Vellore","doi-asserted-by":"publisher","award":["12054(DIAGNO)"],"award-info":[{"award-number":["12054(DIAGNO)"]}],"id":[{"id":"10.13039\/501100005918","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the accuracy of high\u2010risk human papillomavirus (HPV) DNA samples on filter paper in comparison to specimen transport medium (STM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a cross\u2010sectional diagnostic study of 42 consecutive women who were prospectively recruited. Each had self\u2010collected vaginal samples on filter paper, physician\u2010collected cervical samples on filter paper, and physician\u2010collected cervical samples in STM. HPV DNA testing was performed with a Hybrid Capture 2 system (Qiagen). Sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV), and agreement of filter paper methods with the standard procedure were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall prevalence of HPV in STM was 67.5%. Detection of HPV DNA in the physician\u2010collected cervical samples on filter paper had a sensitivity of 77.8%, a specificity of 100%, a PPV of 100%, and an NPV of 68.4%. The patient's self\u2010sampling on filter paper had a sensitivity of 66.7%, a specificity of 100%, a PPV of 100%, and an NPV of 59.1%. The agreement between STM method and physician\u2010collected sample on filter paper was substantial, (\u03ba\u2009=\u20090.695, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), while the agreement between STM and self\u2010collected samples on filter paper was moderate (\u03ba\u2009=\u20090.565, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Most patients reported that self\u2010collection was acceptable (100%), painless (95%), and not embarrassing (95%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Filter paper, with dried self\u2010collected vaginal samples, can be used to detect high\u2010risk HPV with acceptable accuracy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14906","type":"journal-article","created":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T03:54:00Z","timestamp":1685764440000},"page":"660-666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Diagnostic study of human papillomavirus <scp>DNA<\/scp> detection in cervical and vaginal samples using the filter paper card"],"prefix":"10.1002","volume":"163","author":[{"given":"Chiyancheri Koroth","family":"Ramesan","sequence":"first","affiliation":[{"name":"Department of Gynaecologic Oncology Christian Medical College  Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Dickson","family":"Calvin","sequence":"additional","affiliation":[{"name":"Department of Clinical Virology Christian Medical College  Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5533-0184","authenticated-orcid":false,"given":"Anitha","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Gynaecologic Oncology Christian Medical College  Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Department of Clinical Virology Christian Medical College  Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7770-459X","authenticated-orcid":false,"given":"Rajesh","family":"Kannangai","sequence":"additional","affiliation":[{"name":"Department of Clinical Virology Christian Medical College  Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2873-9101","authenticated-orcid":false,"given":"Priya","family":"Abraham","sequence":"additional","affiliation":[{"name":"Department of Clinical Virology Christian Medical College  Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9318-566X","authenticated-orcid":false,"given":"Abraham","family":"Peedicayil","sequence":"additional","affiliation":[{"name":"Department of Gynaecologic Oncology Christian Medical College  Vellore India"},{"name":"Sultan Qaboos Comprehensive Cancer Care &amp; Research Centre  Muscat Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2020.02.008"},{"key":"e_1_2_11_3_1","first-page":"25","volume-title":"Global Strategy to Accelerate the Elimination of Cervical Cancer as a Public Health Problem","year":"2020"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-51-7-606"},{"key":"e_1_2_11_5_1","unstructured":"nMaster 2.0 \u2010 Sample Size Software [Internet].2022.https:\/\/www.cmc\u2010biostatistics.ac.in\/nmaster\/. 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