{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T04:15:23Z","timestamp":1776744923933,"version":"3.51.2"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["226\u20102022\u201000049"],"award-info":[{"award-number":["226\u20102022\u201000049"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2021YFC2700701"],"award-info":[{"award-number":["2021YFC2700701"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY21H040004"],"award-info":[{"award-number":["LY21H040004"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the treatment effects of laparoscopy versus laparotomy on heterotopic pregnancy (HP) after in vitro fertilization\u2010embryo transfer (IVF\u2010ET).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The retrospective case\u2013control study enrolled 109 patients diagnosed with HP after IVF\u2010ET treatment in our hospital from January 2009 to March 2020. All patients received surgical treatment by either laparoscopy or laparotomy. Data for general characteristics, diagnostic features, surgical parameters, as well as perinatal and neonatal outcomes were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010two patients received laparoscopy and 47 received laparotomy. Significantly lower percentage of large hemoperitoneum (<jats:italic>P<\/jats:italic>\u2009=\u20090.001), shorter surgery duration (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), less intraoperative blood loss (<jats:italic>P<\/jats:italic>\u2009=\u20090.001), higher rates of general anesthesia (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and lower cesarean section rates for singletons (<jats:italic>P<\/jats:italic>\u2009=\u20090.003) were found in the laparoscopy group. The perinatal and neonatal outcomes were comparable between the two groups. When interstitial pregnancy was considered alone, the surgical blood loss was significantly reduced in the laparoscopy group (<jats:italic>P<\/jats:italic>\u2009=\u20090.021), but there was no significant difference in hemoperitoneum, surgery duration, or perinatal and neonatal outcomes in singletons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both laparoscopy and laparotomy are effective surgical treatments for HP after IVF\u2010ET. Laparoscopy is minimally invasive but laparotomy can be an alternative in emergency situations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14919","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T11:49:45Z","timestamp":1686829785000},"page":"689-696","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Treatment effects of laparoscopy versus laparotomy on heterotopic pregnancy after in vitro fertilization and embryo transfer"],"prefix":"10.1002","volume":"163","author":[{"given":"Xijing","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Reproductive Endocrinology, Women's Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology, Women's Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenting","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology, Women's Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luna","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology, Women's Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingping","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology, Women's Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yimin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Reproductive Endocrinology, Women's Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.5.1100"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.05.085"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1742271X17710965"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2017.03.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina56120665"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.11.023"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.07.1245"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2020.06.005"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-017-4384-y"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviscsurg.2015.09.017"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12069"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2019.09.783"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0000000000000048"},{"key":"e_1_2_9_15_1","first-page":"210","article-title":"Adnexal torsion in the first trimester of pregnancy: diagnosis, laparoscopic management, and review of the literature","volume":"30","author":"Bras R","year":"2017","journal-title":"Surg Technol Int"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2015.11.013"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60693-1"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2004.00350.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009465900824"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2012.06.006"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2015.02.025"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.JAA.0000654012.56086.97"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2010.01.016"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-008-9989-6"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-239423"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2017.12.001"}],"container-title":["International Journal of Gynecology &amp; 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