{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T02:35:27Z","timestamp":1787884527208,"version":"build-2784847793"},"reference-count":88,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T00:00:00Z","timestamp":1691107200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Anemia affects 36% of pregnant women worldwide. Of those affected, around 40% is due to iron deficiency (ID). Iron is an essential micronutrient involved in vital processes such as erythropoiesis, immune responses, and importantly\u2014during pregnancy\u2014placental and fetal development. Although menstrual bleeding can impact the incidence of ID even before the onset of pregnancy, this narrative review is pregnancy focused and will explore the impact of ID on placental development and iron uptake, fetal development and immunity, and maternal and infant susceptibility to infection. Although there have been advances in this area of research, much is needed to understand the regulation of iron and the effects of ID during pregnancy. Notably, more human studies are essential to generate the best evidence to advance strategies to reduce the incidence of ID during pregnancy to improve maternal, neonatal, and infant health.<\/jats:p>","DOI":"10.1002\/ijgo.14944","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T03:17:19Z","timestamp":1691119039000},"page":"14-22","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Iron deficiency, pregnancy, and neonatal development"],"prefix":"10.1002","volume":"162","author":[{"given":"Ricardo","family":"Ataide","sequence":"first","affiliation":[{"name":"Population Health and Immunity Division The Walter and Eliza Hall Institute  Melbourne Australia"},{"name":"Department of Infectious Diseases The Peter Doherty Institute for Infection and Immunity  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Fielding","sequence":"additional","affiliation":[{"name":"Population Health and Immunity Division The Walter and Eliza Hall Institute  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sant\u2010Rayn","family":"Pasricha","sequence":"additional","affiliation":[{"name":"Population Health and Immunity Division The Walter and Eliza Hall Institute  Melbourne Australia"},{"name":"Department of Medical Biology The University of Melbourne  Melbourne Australia"},{"name":"Diagnostic Hematology The Royal Melbourne Hospital  Parkville Australia"},{"name":"Clinical Hematology at the Royal Melbourne Hospital and Peter MacCallum Cancer Centre  Parkville Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cavan","family":"Bennett","sequence":"additional","affiliation":[{"name":"Population Health and Immunity Division The Walter and Eliza Hall Institute  Melbourne Australia"},{"name":"Department of Medical Biology The University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(22)00084-5"},{"key":"e_1_2_11_3_1","unstructured":"World Health Organization.Global Health Observatory. Prevalence of anaemia in pregnant women aged 15\u201349. Accessed January 12 2023.https:\/\/www.who.int\/data\/gho\/indicator\u2010metadata\u2010registry\/imr\u2010details\/4552"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14092"},{"key":"e_1_2_11_5_1","volume-title":"Nutritional Anaemias: Tools for Effective Prevention","author":"World Health Organization","year":"2017"},{"key":"e_1_2_11_6_1","volume-title":"Adjusting Hemoglobin Values in Program Surveys","author":"Nestel P","year":"2002"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.07.001"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(18)30078-0"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f3443"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13978"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20051493"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/15513815.2019.1587120"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665113003637"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxab005"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI127341"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuw009"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00525.2003"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-020-01201-y"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2011.00428.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06216.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3863"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201540558"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002854"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01313"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.14951"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-10-47"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-018-1146-z"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-022-04177-8"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1086\/589512"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/nure.12049"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/nure.12049"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00008.2013"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.232124"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8040589"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00160.2015"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-05-786590"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104742"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2668-z"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-258467"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu6083062"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2021.12.018"},{"key":"e_1_2_11_42_1","first-page":"1395","article-title":"The iron regulatory hormone hepcidin is decreased in pregnancy: a prospective longitudinal study","volume":"51","author":"Santen S","year":"2013","journal-title":"Clin Chem Lab Med"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.116.245373"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-20-0271"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.117.155812"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI41211"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-100814-125620"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2011.11.017"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016349009028705"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2019.11.003"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqab215"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2983"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.06.028"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198501103120204"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-015-9841-6"},{"key":"e_1_2_11_56_1","first-page":"127","article-title":"Effect of dietary iron on fetal growth in pregnant mice","volume":"63","author":"Hubbard AC","year":"2013","journal-title":"Comp Med"},{"key":"e_1_2_11_57_1","first-page":"687","article-title":"Effect of iron deficiency on fetal growth in the pregnant mouse","volume":"51","author":"Hubbard AC","year":"2012","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.9496"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23184"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1177\/156482650702800407"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des026"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2011.06.003"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1017\/S136898002100166X"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-306328"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1080\/16549716.2020.1870421"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00278-7"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016340802595993"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034187"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.816282"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2020.100864"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2019.00116"},{"key":"e_1_2_11_72_1","first-page":"164","article-title":"Hepcidin\u2010mediated hypoferremia disrupts immune responses to vaccination and infection","volume":"2","author":"Frost JN","year":"2021","journal-title":"Med (N Y)"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005395"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-184"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.06.018"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-015-0999-6"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fml012"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.9.2345"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114521001975"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/86.1.64"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-018-0140-9"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mjafi.2019.11.002"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087743"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2013.12.007"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-5-55"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0253974"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14040836"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30066-5"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(11)70341-3"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.14944","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T23:55:30Z","timestamp":1692316530000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.14944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":88,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/ijgo.14944"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.14944","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"2023-08-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}