{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:46:17Z","timestamp":1790279177701,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["(ICMR) (5\/9\/1206\/2019\u2010Nut)"],"award-info":[{"award-number":["(ICMR) (5\/9\/1206\/2019\u2010Nut)"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Pregnancy, a nutritionally demanding situation in terms of macro\u2010 and micronutrient supply owing to heightened maternal, placental, and fetal needs, significantly affects thiamine reserves. Thiamine deficiency during pregnancy and the postpartum period, presenting with varied manifestations and outcomes, is a relatively common condition in our population. The study aimed to understand the various manifestations and outcomes of acute thiamine deficiency in pregnant and postpartum women, emphasizing the significance of early recognition and thiamine therapy to prevent serious complications during pregnancy and after childbirth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective study conducted in a tertiary care center in North India enrolled consecutive pregnant and postpartum women presenting with clinical features consistent with thiamine deficiency disorders, such as thiamine deficiency\u2010related neuropathy, high\u2010output heart failure, heart failure with reduced ejection fraction, Wernicke's encephalopathy, gastric beriberi, and thiamine\u2010responsive acute pulmonary hypertension. In addition to capturing medical history including drug intake, dietary consumption, and comorbidities, women underwent brief relevant clinical examinations and laboratory assessments, including whole\u2010blood thiamine levels. Response to intravenous thiamine supplementation was also monitored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data of 31 women (12 pregnant, 19 postpartum) with a diagnosis of acute thiamine deficiency and a mean age of 28.88\u2009\u00b1\u20092.69\u2009years were analyzed. The mean thiamine level was 1.28\u2009\u00b1\u20090.44\u2009\u03bcg\/dL with mean blood lactate of 3.46\u2009\u00b1\u20093.33. The most common presentation was gastric beriberi (<jats:italic>n<\/jats:italic>\u2009=\u200910), followed by paraparesis (<jats:italic>n<\/jats:italic>\u2009=\u20096), high\u2010output heart failure (<jats:italic>n<\/jats:italic>\u2009=\u20096), acute pulmonary hypertension, heart failure with reduced ejection fraction (<jats:italic>n<\/jats:italic>\u2009=\u20093 each), and an acute confusional state (<jats:italic>n<\/jats:italic>\u2009=\u20092). All patients responded to thiamine challenge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the context of borderline thiamine status, particularly in our population with endemic thiamine deficiency and heightened demand for thiamine during pregnancy and the peripartum period, the deficiency can have varied and serious manifestations of dry and wet beriberi. Early recognition of the clinical features and thiamine therapy can be life\u2010saving. There is a need for validated clinical criteria owing to the non\u2010availability of thiamine testing in resource\u2010limited settings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.14989","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T11:20:04Z","timestamp":1689592804000},"page":"157-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Descriptive spectrum of thiamine deficiency in pregnancy: A\u00a0potentially preventable condition"],"prefix":"10.1002","volume":"164","author":[{"given":"Sobia","family":"Nisar","sequence":"first","affiliation":[{"name":"Department of Medicine Government Medical College  Srinagar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7745-4954","authenticated-orcid":false,"given":"Ozaifa","family":"Kareem","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Kashmir  Srinagar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umar","family":"Muzaffer","sequence":"additional","affiliation":[{"name":"Department of Medicine Government Medical College  Srinagar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masood","family":"Tanvir","sequence":"additional","affiliation":[{"name":"Department of Medicine Government Medical College  Srinagar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd. 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