{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T11:36:33Z","timestamp":1770464193923,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,8,6]],"date-time":"2023-08-06T00:00:00Z","timestamp":1691280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the impact of treatment of subclinical hypothyroidism (SCH) on short\u2010term pregnancy outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Data from 4526 consecutive women with singleton pregnancies who delivered between January 2015 and December 2017 were analyzed. SCH was defined as a thyroid\u2010stimulating hormone (TSH) level between 2.5 and 10\u2009mU\/mL with normal free thyroxine. Of those with SCH, some were treated but others were not. These two groups were compared using <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> and Student <jats:italic>t<\/jats:italic> tests for categorical and continuous variables, respectively. Multiple logistic regression models, adjusted for maternal age, body mass index, parity, gestation at TSH measurement, and gestational diabetes mellitus status, were used to investigate the effect of treatment on pregnancy and neonatal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 1227 (27.1%) of 4526 women had SCH, of whom 393 (32.0%) were treated. The mean age and body mass index were similar in both groups. The mean gestation at measuring of TSH was 11.7\u2009\u00b1\u20096.5\u2009weeks. There was no significant difference in pregnancy or neonatal outcomes between the two groups. A sub\u2010group analysis when SCH was defined as TSH 4.0\u2009mU\/mL or greater showed a higher rate of large for gestational age and lower rates of low birth weight and small for gestational age in the treated group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of SCH based on the international guidelines threshold is high in India. Treatment of SCH did not show any difference in pregnancy and neonatal outcomes in this study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15021","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T05:34:22Z","timestamp":1691386462000},"page":"677-683","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of treating subclinical hypothyroidism in pregnancy in India: Are we treating too many for little gain? A retrospective cohort study"],"prefix":"10.1002","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3886-4501","authenticated-orcid":false,"given":"Uma","family":"Ram","sequence":"first","affiliation":[{"name":"Seethapathy Clinic &amp; Hospital  Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathangi","family":"Thirunavukkarasu","sequence":"additional","affiliation":[{"name":"Seethapathy Clinic &amp; Hospital  Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishna","family":"Shyam","sequence":"additional","affiliation":[{"name":"SRM Medical College Hospital and Research Centre  Katankallathur India"},{"name":"Mahatma Gandhi Medical College and Research Institute  Pondicherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonas","family":"Ghebremichael\u2010Weldeselassie","sequence":"additional","affiliation":[{"name":"Division of Health Sciences, Warwick Medical School University of Warwick  Warwick UK"},{"name":"UK School of Mathematics and Statistics The Open University  Milton Keynes UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nithya","family":"Sukumar","sequence":"additional","affiliation":[{"name":"Populations, Evidence and Technologies, Division of hHealth Sciences, Warwick Medical School University of Warwick  Warwick UK"},{"name":"Academic Department of Diabetes, Endocrinology and Metabolism George Eliot Hospital  Nuneaton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ponnusamy","family":"Saravanan","sequence":"additional","affiliation":[{"name":"Populations, Evidence and Technologies, Division of hHealth Sciences, Warwick Medical School University of Warwick  Warwick UK"},{"name":"Academic Department of Diabetes, Endocrinology and Metabolism George Eliot Hospital  Nuneaton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2038"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.179992"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0418"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2011.0087"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1674"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.01673.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2015.35.2.198"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0457"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1615312"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g4929"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606205"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-02378"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1106104"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i6865"},{"key":"e_1_2_9_16_1","unstructured":"Maternal Health Division Ministry of Health & Family Welfare Government of India.National Guidelines for Screening of Hypothyroidism during Pregnancy India. 2022.http:\/\/nhm.gov.in\/images\/pdf\/programmes\/maternal\u2010health\/guidelines\/National_Guidelines_for_Screening_of_Hypothyroidism_during_Pregnancy.pdf"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.192903"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.172239"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60364-4"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.109712"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13224-019-01272-w"},{"key":"e_1_2_9_22_1","first-page":"QC01","article-title":"Feto\u2010maternal outcome using new screening criteria of serum TSH for diagnosing hypothyroidism in pregnancy","volume":"9","author":"Joshi D","year":"2015","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12751"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13925"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(22)00007-9"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2009"}],"container-title":["International Journal of Gynecology &amp; 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