{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T19:20:34Z","timestamp":1776540034799,"version":"3.51.2"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T00:00:00Z","timestamp":1692921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess whether earlier administration of antibiotic prophylaxis after prelabor rupture of membranes (PROM) at term would decrease the incidence of maternal and neonatal infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective cohort study comparing women with term PROM who were initiated antibiotic prophylaxis within or after 6\u2009h, and within or after 12\u2009h from PROM to delivery during January 2019 to December 2021. Women with term PROM receiving cephalosporin and without contraindications to vaginal delivery or confirmed or suspected infection were included in the study. The primary outcome was puerperal infection, which refers to the reproductive tract infection occurring within 42\u2009days of delivery. The type of pharmacoeconomic evaluation was selected based on the results of compared\u00a0effectiveness between the early group and the late group. Propensity\u2010score matching (PSM) was used to adjust confounding. Subgroup and sensitivity analyses were used to verify the robustness of results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 5353 women with term PROM, including 4331 initiated with antibiotic within 6\u2009h, 1022 after 6\u2009h, 5077 within 12\u2009h, and 276 after 12\u2009h. After PSM, no significant difference was observed in the baseline characteristics of the groups. There was no statistical difference between antibiotic use within 6\u2009h and after 6\u2009h, or within 12\u2009h and after 12\u2009h, in puerperal infection (4.6% vs. 4.3%, <jats:italic>P<\/jats:italic>\u2009=\u20090.826; 2.9% vs. 4.6%, <jats:italic>P<\/jats:italic>\u2009=\u20090.471, respectively), total maternal infection, neonatal sepsis, and total neonatal infection. Cost\u2010minimization analysis showed there was no significant difference between antibiotic use within 6\u2009h and after 6\u2009h, or within 12\u2009h and after 12\u2009h, in direct medical costs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study showed that there was no statistical difference in the efficacy and economy of antibiotic prophylaxis used within 6\u201312\u2009h after rupture of membranes versus after 6\u201312\u2009h in women with term PROM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15045","type":"journal-article","created":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T06:13:59Z","timestamp":1693030439000},"page":"741-749","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Timing of antibiotic prophylaxis in term prelabor rupture of membranes: A retrospective cohort study using propensity\u2010score 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