{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T07:40:35Z","timestamp":1705909235471},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100015691","name":"Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K01AI13068","R01AA024092"],"award-info":[{"award-number":["K01AI13068","R01AA024092"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Poor intrauterine growth has negative impacts for child growth and development and disproportionately affects children living in low\u2010resource settings. In the present study, we investigated relationships between placental pathologies and indicators of poor intrauterine growth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled a longitudinal cohort of 279 mother\u2013infant pairs from Leyte, the Philippines. Placental measures included characteristics, pathological findings, and immunohistochemistry. At birth, intrauterine growth was assessed using anthropometric measures, weight\u2010for\u2010gestational age, and the clinical assessment of nutritional status score (CANSCORE) for determining fetal malnutrition. Multivariate linear regression and log\u2010binomial regression models were applied, controlling for potential confounding factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Maternal vascular malperfusion (MVM) was related to reduced birthweight (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), birth length (<jats:italic>P<\/jats:italic>\u2009=\u20090.002), head circumference (<jats:italic>P<\/jats:italic>\u2009=\u20090.001), and weight\u2010to\u2010length ratio (<jats:italic>P<\/jats:italic>\u2009=\u20090.016). MVM increased the risk for preterm delivery (<jats:italic>P<\/jats:italic>\u2009=\u20090.0005) and small for gestational age (SGA) (<jats:italic>P<\/jats:italic>\u2009=\u20090.016). Acute chorioamnionitis (<jats:italic>P<\/jats:italic>\u2009=\u20090.013) and MVM (<jats:italic>P<\/jats:italic>\u2009=\u20090.021) both led to an increased risk for fetal malnutrition defined by CANSORE&lt;25. Villous tissue activated caspase\u20103 was associated with lower birth length (<jats:italic>P<\/jats:italic>\u2009=\u20090.0006), higher weight\u2010to\u2010length ratio (<jats:italic>P<\/jats:italic>\u2009=\u20090.004), reduced risks for SGA (<jats:italic>P<\/jats:italic>\u2009=\u20090.011) and low weight\u2010to\u2010length ratio for gestational age (<jats:italic>P<\/jats:italic>\u2009=\u20090.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study applied comprehensive measures for intrauterine growth and demonstrates that low placental weight and placental pathology, chiefly MVM, contribute to poor intrauterine growth. A better understanding of the mechanistic role of specific placental pathologies on adverse newborn outcomes will provide opportunities for reducing incidence of poor intrauterine growth and associated long\u2010term morbidities.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15047","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T15:49:44Z","timestamp":1692632984000},"page":"750-757","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations between placental pathology and poor intrauterine growth among a cohort of mother\u2013infant singleton pairs in Leyte, the Philippines"],"prefix":"10.1002","volume":"164","author":[{"given":"Susannah","family":"Colt","sequence":"first","affiliation":[{"name":"Center for International Health Research, Rhode Island Hospital The Warren Alpert Medical School of Brown University  Providence Rhode Island USA"},{"name":"Department of Pediatrics 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