{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T10:00:39Z","timestamp":1766138439885,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:00:00Z","timestamp":1696377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81601276"],"award-info":[{"award-number":["81601276"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021MH012"],"award-info":[{"award-number":["ZR2021MH012"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The present study aimed to investigate the effect of long\u2010acting gonadotropin\u2010releasing hormone agonist (GnRHa) long protocol on in vitro fertilization\/intracytoplasmic sperm injection (IVF\/ICSI) outcomes of patients with repeated implantation failure (RIF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present study was carried out from June 1, 2016 to June 30, 2021. A total of 665 patients with RIF were enrolled into the study and classified by the ovarian stimulation protocols. The outcome parameters were compared in each group. In addition, we evaluated the expression of homeobox A10 (HOXA10), integrin \u03b23 and leukemia inhibitory factor (LIF) in endometrial tissues between groups by quantitative RT\u2010PCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients who received the long\u2010acting GnRHa long protocol had significantly higher clinical pregnancy rates (58.0%, 41.7% and 39.9%, respectively; <jats:italic>P<\/jats:italic>\u2009=\u20090.008 and 0.003), implantation rates (38.1%, 30.3%, and 30.1%, respectively; <jats:italic>P<\/jats:italic>\u2009=\u20090.001 and\u2009&lt;0.001) and live birth rates (50.3%, 36.3%, and 31.3%, respectively; <jats:italic>P<\/jats:italic>\u2009=\u20090.020 and 0.002) compared with the short\u2010acting GnRHa long protocol and GnRH antagonist protocol. In addition, we found that long\u2010acting GnRHa could improve the expression of HOXA10 (<jats:italic>P\u2009&lt;<\/jats:italic>\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The long\u2010acting GnRHa long protocol could improve endometrial receptivity and IVF\/ICSI clinical outcomes of RIF patients compared with the short\u2010acting GnRHa long protocol and GnRH antagonist protocol.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15070","type":"journal-article","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T17:47:37Z","timestamp":1696441657000},"page":"563-570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of the long\u2010acting gonadotropin\u2010releasing hormone agonist long protocol on <scp>IVF<\/scp>\/<scp>ICSI<\/scp> outcomes of patients with repeated implantation failure"],"prefix":"10.1002","volume":"164","author":[{"given":"Xuemei","family":"Chen","sequence":"first","affiliation":[{"name":"Binzhou Medical University  Yantai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Yantai Yuhuangding Hospital  Yantai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanping","family":"Xu","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Yantai Yuhuangding Hospital  Yantai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenshu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Yantai Yuhuangding Hospital  Yantai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuzhu","family":"Wang","sequence":"additional","affiliation":[{"name":"Weifang Medical University  Weifang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shulei","family":"Shi","sequence":"additional","affiliation":[{"name":"Weifang Medical University  Weifang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9636-1625","authenticated-orcid":false,"given":"Xuemei","family":"Liu","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Yantai Yuhuangding Hospital  Yantai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmy044"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-021-00810-4"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.841437"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-019-05047-6"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2019.01.001"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-007-9164-3"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa086"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719118816835"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.03.030"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13933"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.916447"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2018.1528221"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103210"},{"issue":"11","key":"e_1_2_11_15_1","article-title":"Long\u2010term GnRH agonist therapy before in vitro fertilisation (IVF) for improving fertility outcomes in women with endometriosis","volume":"2019","author":"Georgiou EX","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2014.40743"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/10.suppl_2.60"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90427-Q"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000009577"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2014.05.011"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.05.064"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020666"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)00519-7"}],"container-title":["International Journal of Gynecology &amp; 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