{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:39:05Z","timestamp":1792024745765,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effect of age on the association between maternal body mass index (BMI) and cumulative live birth rates (CLBRs) following in vitro fertilization treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We retrospectively analyzed the data of 26\u2009567 women undergoing in vitro fertilization\/intracytoplasmic sperm injection from 2016 to 2019. We conducted multivariate regression analysis of the association between CLBRs and maternal BMI and age category.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 16\u2009626 (62.58%) patients achieved a live birth. Women with obesity had significantly decreased CLBRs compared with women who had normal weight (odds ratio [OR] 0.73 [95% confidence interval (CI), 0.66\u20130.80]). The significant interaction between age and BMI suggested that the impact of BMI on CLBRs was moderated by women's age (<jats:italic>P<\/jats:italic> interaction &lt;0.001). The association between obesity and CLBRs was inverse among women aged &lt;30\u2009years (OR, 0.63 [95% CI, 0.54\u20130.73]), 30 to 34\u2009years (OR, 0.79 [95% CI, 0.67\u20130.93]), and 35 to 37\u2009years (OR, 0.71 [95% CI, 0.52\u20130.98]); however, decreases in CLBRs with obesity were not observed in women aged 38 to 40\u2009years (OR, 1.17 [95% CI, 0.70\u20131.94]) and\u2009\u2265\u200941\u2009years (OR, 1.25 [95% CI, 0.53\u20132.96]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maternal obesity was significantly associated with a lower likelihood of having a live birth, but the risk differed according to women's age. A higher BMI might have a less\u2010pronounced detrimental effect with increasing age.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15071","type":"journal-article","created":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T06:12:39Z","timestamp":1694239959000},"page":"578-586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association of overweight and obesity with cumulative live birth rates according to women's age: A cohort study of 26\u2009567 treatment cycles"],"prefix":"10.1002","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0890-8913","authenticated-orcid":false,"given":"He","family":"Cai","sequence":"first","affiliation":[{"name":"Assisted Reproduction Center Northwest Women's and Children's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Xue","sequence":"additional","affiliation":[{"name":"Assisted Reproduction Center Northwest Women's and Children's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Liu","sequence":"additional","affiliation":[{"name":"Assisted Reproduction Center Northwest Women's and Children's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Bai","sequence":"additional","affiliation":[{"name":"Assisted Reproduction Center Northwest Women's and Children's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4261-6818","authenticated-orcid":false,"given":"Juanzi","family":"Shi","sequence":"additional","affiliation":[{"name":"Assisted Reproduction Center Northwest Women's and Children's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(21)00047-4"},{"key":"e_1_2_10_3_1","first-page":"83","article-title":"Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults\u2014study on optimal cut\u2010off points of body mass index and waist circumference in Chinese adults","volume":"15","author":"Zhou B\u2010F","year":"2002","journal-title":"Biomed Environ Sci"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.01.017"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmz011"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.09.139"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.6295"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13923"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/inthealth\/ihx072"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1505297"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.14597"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2022.07.001"},{"key":"e_1_2_10_13_1","first-page":"2010","article-title":"Cumulative live birth rates and number of oocytes retrieved in women of advanced age. A single centre analysis including 4500 women \u226538\u2009years old","volume":"33","author":"Devesa M","year":"2018","journal-title":"Hum Reprod"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.01.035"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den188"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2022.04.026"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.06.005"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.05.043"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmv057"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.11.008"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2021.08.018"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.02.114"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/14647270701731290"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.00994.x"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.15071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T07:16:51Z","timestamp":1705907811000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.15071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,8]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/ijgo.15071"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.15071","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,8]]},"assertion":[{"value":"2023-03-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}