{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:38:38Z","timestamp":1787647118516,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effect of low\u2010molecular\u2010weight heparin (LMWH) on placenta\u2010mediated fetal growth restriction (FGR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cohort of 570 pregnant women diagnosed with placenta\u2010mediated FGR were enrolled from January 1, 2015 through to December 31, 2021. A birth database, including demographic data, antenatal complications, and detailed delivery and newborn data, was created to collect variables from the Hospital Information System (HIS) Database. The unique personal registration number, assigned to each patient on first registration with HIS in the West China Second University Hospital, was used to link these patients. LMWH use was defined as at least 1\u2010week prescription from diagnosis of placenta\u2010mediated FGR. Pregnant women received LMWH (Enoxaparin 4000\u2009IU\/day) by self\u2010administered subcutaneous injection only when they agreed and signed informed consent. Primary outcome was intrauterine fetal death after 20\u2009weeks of pregnancy. Secondary outcomes included preterm birth (PB), Apgar score less than 7 at 1\u2009min, admission to neonatal intensive care unit (NICU), and birth weight. Logistic regression analysis was conducted to compute adjusted odds ratio (aOR) with 95% confidence intervals (CI) for outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After controlling for confounders, LMWH use was associated with a decreased risk of intrauterine fetal death (aOR 2.49, 95% CI 1.35\u20134.57, <jats:italic>P<\/jats:italic>\u2009=\u20090.003), PB before 37\u2009weeks of pregnancy (aOR 3.35, 95% CI 2.14\u20135.23, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), PB before 34\u2009weeks of pregnancy (aOR 2.25, 95% CI 1.36\u20133.74, <jats:italic>P\u2009=<\/jats:italic>\u20090.002), Apgar score less than 7 at 1\u2009min (aOR 2.25, 95% CI 1.36\u20133.74, <jats:italic>P<\/jats:italic>\u2009=\u20090.002), NICU admission (aOR 2.29, 95% CI 1.48\u20133.55, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Using LMWH increased the mean birth weight in PB before 32\u2009weeks of pregnancy (mean\u2009\u00b1\u2009standard deviation [SD] 1126.4\u2009\u00b1\u2009520.0\u2009g, <jats:italic>P<\/jats:italic>\u2009=\u20090.020), PB before 37\u2009weeks of pregnancy (mean\u2009\u00b1\u2009SD 1563.9\u2009\u00b1\u2009502.7\u2009g, <jats:italic>P<\/jats:italic>\u2009=\u20090.019), early\u2010onset FGR (mean\u2009\u00b1\u2009SD 2125.2\u2009\u00b1\u2009665.7\u2009g, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), late\u2010onset FGR (mean\u2009\u00b1\u2009SD 2343.4\u2009\u00b1\u2009507.9, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and non\u2010severe FGR (mean\u2009\u00b1\u2009SD 2231.1\u2009\u00b1\u2009607.2\u2009g, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Use of LMWH can significantly improve the fetal and neonatal outcomes among pregnant women with placenta\u2010mediated FGR, particularly reducing the risk of intrauterine fetal death.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15098","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T05:48:05Z","timestamp":1695188885000},"page":"220-228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of low\u2010molecular\u2010weight heparin on placenta\u2010mediated fetal growth restriction in a tertiary referral hospital: A 7\u2010year retrospective cohort study"],"prefix":"10.1002","volume":"165","author":[{"given":"Jinfeng","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, West China Second University Hospital Sichuan University  Chengdu China"},{"name":"West China School of Medicine Sichuan University  Chengdu China"},{"name":"The Key Laboratory of Birth Defects and Related Diseases of Women and Children Sichuan University  Chengdu China"},{"name":"International Center for 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