{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:08:02Z","timestamp":1781276882800,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:00:00Z","timestamp":1694995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471457"],"award-info":[{"award-number":["81471457"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20171126"],"award-info":[{"award-number":["BK20171126"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to investigate the influence of ratio of serum luteinizing hormone (LH) on gonadotropin\u2010releasing hormone antagonist (GnRH\u2010ant) day to basal LH (hLH\/bLH) on in\u2010vitro fertilization or intracytoplasmic sperm injection (IVF\/ICSI) outcome in polycystic ovary syndrome (PCOS) women who received GnRH\u2010ant protocol for controlled ovarian hyperstimulation (COH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study was conducted in women with PCOS (<jats:italic>n<\/jats:italic>\u2009=\u20091116) who underwent the GnRH\u2010ant protocol for COH between 2015 and 2022 and were stratified as group A (hLH\/bLH\u2009&lt;\u20091, <jats:italic>n<\/jats:italic>\u2009=\u2009489) and group B (hLH\/bLH\u2009\u2265\u20091, <jats:italic>n<\/jats:italic>\u2009=\u2009627) according to the variation of serum LH. The outcomes of COH and the first frozen embryo transfer (FET) cycle were compared between group A, B and the linear relationship between hLH\/bLH ratio and IVF\/ICSI outcomes were studied by multivariate linear regression analysis and restricted cubic spline (RCS) models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were significant differences in baseline characteristics and outcomes between group A and B. Group A had higher levels of bLH, AMH, estradiol (E2) on GnRH\u2010ant start day and lower levels of LH on GnRH\u2010ant start day. Group B has better ovulation induction outcomes: more retrieved oocytes, normally fertilized oocytes (2PN), cleavage embryos, available embryos and high\u2010quality blastocysts. Multivariate linear regression analysis found no statistically significant connection between hLH\/bLH and clinical outcomes. RCS models showed hLH\/bLH had nonlinear association with outcomes, including number of oocytes retrieved, 2PN, available embryos, incidence of OHSS, chemical pregnancy, clinical pregnancy, abortion and live birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>hLH\/bLH ratio could be a more forward\u2010looking indicator of clinical outcome in women with PCOS undergoing GnRH\u2010ant protocols than LH on trigger day and the ratio of LH level on trigger day to basal LH. hLH\/bLH\u2009=\u20091 may be the best condition for higher live birth rate and lower OHSS rate.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15131","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T06:55:18Z","timestamp":1695106518000},"page":"624-632","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["LH on GnRH\u2010ant day to basal LH affects the IVF\/ICSI outcome of PCOS women undergoing GnRH\u2010antagonist protocol"],"prefix":"10.1002","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6457-0174","authenticated-orcid":false,"given":"Yi","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Luan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital  Nanjing 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