{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T16:15:27Z","timestamp":1768925727090,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T00:00:00Z","timestamp":1694822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We compared efficacy of weight\u2010based (0.4\u2009IU\/kg\/h) versus fixed\u2010dose (34\u2009IU\/h) oxytocin infusion during cesarean section.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The oxytocin infusion in either group (<jats:italic>n<\/jats:italic>\u2009=\u200932 each) was initiated upon cord clamping. Primary outcome measure was adequacy of uterine tone at 4\u2009min after initiating oxytocin infusion. Oxytocin associated side effects were also observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significantly less oxytocin was used with the weight\u2010based versus fixed\u2010dose regimen (16.3 [11.2\u201322.4] IU vs 20.4 [15.8\u201326.9] IU; <jats:italic>P<\/jats:italic>\u2009=\u20090.036). Incidence of adequate uterine tone was clinically greater but not significantly different with the weight\u2010based versus fixed\u2010dose regimen (81.3% vs 71.9%; <jats:italic>P<\/jats:italic>\u2009=\u20090.376). The weight\u2010based regimen was associated with clinically lesser, although not statistically significant need for rescue oxytocin (25% vs 46.9%; <jats:italic>P<\/jats:italic>\u2009=\u20090.068) and additional uterotonic (9.4% vs 15.6%; <jats:italic>P<\/jats:italic>\u2009=\u20090.708); as well as oxytocin associated side effects (hypotension [34.4% vs 46.9%; <jats:italic>P<\/jats:italic>\u2009=\u20090.309], nausea\/vomiting [18.8% vs 40.6%; <jats:italic>P<\/jats:italic>\u2009=\u20090.055], and ST\u2010T changes [0% vs 3.1%; <jats:italic>P<\/jats:italic>\u2009=\u20091.000]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Weight\u2010based oxytocin was not significantly different from the fixed\u2010dose regimen in terms of uterotonic efficacy or associated side\u2010effects, despite significantly lower doses being used. Use of weight\u2010based oxytocin infusion (0.4\u2009IU\/kg\/h) can be considered in clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>Clinical Trial Registry of India (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ctri.nic.in\">ctri.nic.in<\/jats:ext-link>, number. CTRI\/2021\/01\/030642).<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15138","type":"journal-article","created":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T03:53:42Z","timestamp":1694836422000},"page":"985-991","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Weight\u2010based versus fixed dose oxytocin infusion for preventing uterine atony during cesarean section in laboring patients: A randomized trial"],"prefix":"10.1002","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5331-6832","authenticated-orcid":false,"given":"Asha","family":"Tyagi","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Critical Care University College of Medical Sciences and GTB Hospital  Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poonam","family":"Bodh","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care University College of Medical Sciences and GTB Hospital  Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Medha","family":"Mohta","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care University College of Medical Sciences and GTB Hospital  Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bindiya","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University College of Medical Sciences and GTB Hospital  Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14757"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AIA.0000000000000016"},{"key":"e_1_2_9_4_1","volume-title":"WHO recommendations: uterotonics for the prevention of postpartum haemorrhage","year":"2018"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-010-9297-1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000191529.52596.c0"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000142709.04450.bd"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000682"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000781"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/ael302"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(01)01479-X"},{"key":"e_1_2_9_12_1","first-page":"667","volume-title":"Basic and Clinical Pharmacology","author":"Long RK","year":"2018"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15322"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2015.04.038"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-044754"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1694982"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2022.100627"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14944"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004395"},{"issue":"35","key":"e_1_2_9_20_1","first-page":"e1","article-title":"Oxytocin: new perspectives on an old drug","volume":"200","author":"Clark SL","year":"2009","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_9_21_1","first-page":"782","volume-title":"Goodman and Gilman's the Pharmacological Basis of Therapeutics","author":"Gilman GA","year":"2018"}],"container-title":["International Journal of Gynecology &amp; 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