{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:28:08Z","timestamp":1777984088028,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the materno\u2010fetal outcome of high\u2010risk women using placental growth factor (PlGF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective cohort study was performed at a tertiary care hospital from September 2019 to April 2022. Women having clinically major or minor high risk factors of pre\u2010eclampsia were included after consent. The placental growth factor (PlGF) was evaluated among high\u2010risk women at 20\u201322, 28\u201330, and 34\u201336\u2009weeks of gestation. They were followed throughout pregnancy until delivery. Materno\u2010fetal outcome was evaluated based on PlGF levels at three different time points. The gestational age specific cutoff was derived. Those with levels below cutoff were taken as cases and those with values above cutoff were considered as controls. The odds of having complications if the PlGF was below cutoff were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 287 high\u2010risk women, 46 (16%) had pre\u2010eclampsia (PE). The derived cutoff of PlGF was 224, 211, and 176\u2009pg\/mL at 20\u201322, 28\u201330, and 34\u201336\u2009weeks, respectively. With PlGF below the cutoff at 20\u201322\u2009weeks the odds of having HELLP syndrome was 15.8, with low PlGF at 28\u201330\u2009weeks the odds for developing early onset PE was 11.3. Low PlGF was also significantly associated with preterm delivery <jats:italic>(P\u2009&lt;<\/jats:italic>\u20090.001) and early onset FGR <jats:italic>(P\u2009&lt;<\/jats:italic>\u20090.001). The sensitivity (91.7%) and specificity (78.5%) of PlGF for PE prediction was highest at 28\u201330\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low PlGF at 28\u201330\u2009weeks was associated with high likelihood of developing early onset PE, and the PlGF cutoff should be gestational age specific.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15143","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T07:27:06Z","timestamp":1696922826000},"page":"211-219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Materno\u2010fetal outcome with PlGF above or below cutoff during second half of pregnancy in high\u2010risk women"],"prefix":"10.1002","volume":"165","author":[{"given":"Kirti","family":"Balyan","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology LHMC  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benchumi Y.","family":"Humtso","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology LHMC  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhawana","family":"Meena","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology LHMC  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surbhi","family":"Sapna","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology LHMC  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjali","family":"Rana","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology LHMC  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7472-2020","authenticated-orcid":false,"given":"Manisha","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology LHMC  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10803"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2017.61"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/297397"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341264"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12802"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1704559"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2020.04.004"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2022.10.003"},{"key":"e_1_2_12_10_1","volume-title":"Hypertension in Pregnancy: the Management of Hypertensive Disorders during Pregnancy","author":"National Collaborating Centre for Women's and Children's Health (UK)","year":"2010"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.01.011"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15884"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1148\/109.2.297"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)33212-4"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.17047"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2018.03.007"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004149"},{"issue":"3","key":"e_1_2_12_19_1","first-page":"1","article-title":"Ontario health (quality). Placental growth factor (PlGF)\u2010 based biomarker testing to help diagnose pre\u2010eclampsia in people with suspected pre\u2010eclampsia: a health technology assessment","volume":"23","year":"2023","journal-title":"Ont Health Technol Assess Ser"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.003215"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.13763"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.15143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T15:31:47Z","timestamp":1720193507000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.15143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,10]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/ijgo.15143"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.15143","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,10]]},"assertion":[{"value":"2023-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}