{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:14:25Z","timestamp":1747149265472,"version":"3.40.5"},"reference-count":7,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Superfetation is a very rare occurrence. In the context of assisted reproduction, it has been reported only as an intrauterine pregnancy after ovarian stimulation and\/or embryo transfer in the presence of an undiagnosed ectopic pregnancy. Here we report a case of a 27\u2010year\u2010old anovulatory patient, gravida 1 para 1, who underwent two frozen\u2013thawed single\u2010blastocyst transfers in separate cycles. The patient reported that 12\u2009days after the first transfer, she had menstrual bleeding and stopped her estradiol and progesterone supplementation without undergoing a blood human chorionic gonadotropin (\u03b2hCG) test. At her request, a second cycle was immediately initiated, with endometrial thickness measuring 4\u2009mm. Eleven days after the second transfer, the \u03b2hCG value was inappropriately high. A right tubal pregnancy corresponding to 8 gestational weeks was diagnosed. Laparoscopy revealed a prominent right tubal pregnancy in addition to a significantly smaller left tubal pregnancy. The discordant tubal pregnancies were confirmed histologically. To our knowledge, superfetation involving a second ectopic pregnancy coexistent with a first, contralateral ectopic pregnancy consequent to consecutive in vitro fertilization procedures has not previously been described in the medical literature. This case emphasizes the importance of routine \u03b2hCG testing after every IVF cycle, even if apparently unsuccessful.<\/jats:p>","DOI":"10.1002\/ijgo.15170","type":"journal-article","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T05:56:08Z","timestamp":1696398968000},"page":"562-565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tubal superfetation following frozen\u2013thawed single\u2010embryo transfers in two separate cycles: Case report and literature review"],"prefix":"10.1002","volume":"165","author":[{"given":"Eric","family":"Ohana","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Soroka University Medical Center  Beer Sheva Israel"},{"name":"Faculty of Health Sciences Ben Gurion University of the Negev  Beer Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benzion","family":"Samueli","sequence":"additional","affiliation":[{"name":"Department of Pathology, Soroka University Medical Center, Beer Sheva, Faculty of Health Sciences Ben Gurion University of the Negev  Beer Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moran","family":"Shahar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Soroka University Medical Center  Beer Sheva Israel"},{"name":"Faculty of Health Sciences Ben Gurion University of the Negev  Beer Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avi","family":"Ben\u2010Haroush","sequence":"additional","affiliation":[{"name":"Infertility and IVF Unit, Rabin Medical Center\u2014Beilinson Hospital, Petach Tikva, Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2759-5588","authenticated-orcid":false,"given":"Yoel","family":"Shufaro","sequence":"additional","affiliation":[{"name":"Infertility and IVF Unit, Rabin Medical Center\u2014Beilinson Hospital, Petach Tikva, Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,3]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1080\/jmf.14.4.217.219"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.1016\/S0015-0282(97)00244-6"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.1093\/oxfordjournals.humrep.a019385"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1016\/j.rbmo.2010.01.017"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.1093\/humrep\/deh098"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_1","DOI":"10.1016\/S0015-0282(16)53595-X"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.1093\/humrep\/16.6.1098"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.15170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T04:23:45Z","timestamp":1721190225000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.15170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,3]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/ijgo.15170"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.15170","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"type":"print","value":"0020-7292"},{"type":"electronic","value":"1879-3479"}],"subject":[],"published":{"date-parts":[[2023,10,3]]},"assertion":[{"value":"2023-07-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}