{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:43:46Z","timestamp":1790743426956,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify distinct subphenotypes of severe early\u2010onset pre\u2010eclampsia in Latin America and analyze biomarker and hemodynamic trends between subphenotypes after hospital admission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010center prospective cohort study was conducted in Colombia. The latent class analysis identified subphenotypes using clinical variables, biomarkers, laboratory tests, and maternal hemodynamics. Class\u2010defining variables were restricted to measurements at and 24\u2009h after admission. Primary and secondary outcomes were severe maternal and perinatal complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 49 patients, two subphenotypes were identified: Subphenotype 1 (34.7%) had a higher likelihood of an sFlt\u20101\/PlGF ratio\u2009\u2264\u200938, maternal age\u2009&gt;\u200935, and low probability of TPR\u2009&gt;\u20091400, CO\u2009&lt;8, and IUGR; Subphenotype 2 (65.3%) had a low likelihood of an sFlt\u20101\/PlGF ratio\u2009&lt;\u200938, maternal age\u2009&gt;\u200935, and high probability of TPR\u2009&gt;\u20091400, CO\u2009&lt;8, and IUGR. At 24\u2009h postadmission, 64.7% of subphenotype 1 patients changed to subphenotype 2, while 25% of subphenotype 2 patients were reclassified as subphenotype 1. Subphenotype 1 displayed significant changes in CO and TPR, while subphenotype 2 did not. Maternal complications were more prevalent in subphenotype 2, with an odds ratio of 5.3 (95% CI: 1.3\u201322.0; <jats:italic>P<\/jats:italic>\u2009=\u20090.02), but no significant differences in severe neonatal complications were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We identified two distinct subphenotypes in a Latin American cohort of patients with severe early\u2010onset pre\u2010eclampsia. Subphenotype 2, characterized by higher TPR, sFlt\u20101, and serum creatinine and lower CO and PlGF at admission, was associated with worse maternal outcomes and appeared less modifiable after in\u2010hospital treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15195","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T09:21:37Z","timestamp":1697534497000},"page":"453-461","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Subphenotypes of severe early\u2010onset pre\u2010eclampsia at hospital admission. A Latin American single\u2010center exploratory latent class analysis"],"prefix":"10.1002","volume":"165","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0310-3235","authenticated-orcid":false,"given":"Jose","family":"Rojas\u2010Suarez","sequence":"first","affiliation":[{"name":"Intensive Care and Obstetric Research Group (GRICIO) Universidad de Cartagena  Cartagena Colombia"},{"name":"GINUMED Research Group Corporaci\u00f3n Universitaria Rafael N\u00fa\u00f1ez  Cartagena Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier A.","family":"Carvajal","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics Department Fundaci\u00f3n Valle Del Lili  Cali Colombia"},{"name":"Facultad de Ciencias de la Salud Universidad ICESI  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria P.","family":"Echavarria","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics Department Fundaci\u00f3n Valle Del Lili  Cali Colombia"},{"name":"Facultad de Ciencias de la Salud Universidad ICESI  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Ramos","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud Universidad ICESI  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Zambrano","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud Universidad ICESI  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Hincapie","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud Universidad ICESI  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn E.","family":"Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Cl\u00ednicas Fundaci\u00f3n Valle Del Lili  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Libreros","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Cl\u00ednicas Fundaci\u00f3n Valle Del Lili  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda F.","family":"Escobar","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics Department Fundaci\u00f3n Valle Del Lili  Cali Colombia"},{"name":"Facultad de Ciencias de la Salud Universidad ICESI  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003891"},{"key":"e_1_2_10_3_1","unstructured":"World Bank Country and Lending Groups \u2013 World Bank Data Help Desk. Accessed August 8 2023.https:\/\/datahelpdesk.worldbank.org\/knowledgebase\/articles\/906519\u2010world\u2010bank\u2010country\u2010and\u2010lending\u2010groups"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(14)70227-X"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l2381"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2021.12.003"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2200161"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-017-0766-6"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17335"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004572"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.21949"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.13763"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2019.03.005"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-199412011-00001"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.11.022"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.009595"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20179"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.24858"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23614"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.03.027"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(15)30511-9"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.10.052"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.08.034"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.26633\/RPSP.2022.21"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)35405-6"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12349"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.15195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T04:26:11Z","timestamp":1721190371000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.15195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,17]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/ijgo.15195"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.15195","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,17]]},"assertion":[{"value":"2023-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}