{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:14:29Z","timestamp":1747149269918,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003562","name":"Ministry of Environment","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003562","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Although prior attempts have failed to identify the beneficial effects of intensive fetal monitoring on cerebral palsy, the association between nonreassuring fetal status (NRFS) during labor and the incidence of long\u2010term neurodevelopmental delays in offspring remains unclear. This study aimed to evaluate this association using a nationwide birth cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 72\u2009869 women with singleton deliveries at and after 37\u2009weeks of gestation from the Japan Environment and Children's Study (2011\u20132014) were analyzed. Multivariable logistic regression models were used to analyze the odds ratios (ORs) for neurodevelopmental delays using the Ages &amp; Stages Questionnaire (Third Edition) in offspring aged 3\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The adjusted ORs for personal\u2013social problems were 1.52 (95% confidence interval [CI], 1.06\u20132.16) for offspring delivered vaginally by nulliparous mothers and 1.51 (95% CI, 1.05\u20132.18) (for males, 1.70 [95% CI, 1.15\u20132.50]) for those delivered via cesarean section. No significant changes in adjusted ORs for neurodevelopmental delays were observed among participants without neonatal Apgar scores (ASs) &lt;7 and without umbilical arterial pH (UmA\u2010pH) &lt;7.20.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NRFS during labor was associated with an increased incidence of personal\u2013social problems in offspring aged 3\u2009years. However, this association was not confirmed after excluding participants with neonatal ASs &lt;7 and UmA\u2010pH &lt;7.20. The association between NRFS and offspring's neurodevelopmental delays might vary based on delivery settings, offspring sex, and short\u2010term neonatal outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15206","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T21:54:11Z","timestamp":1700603651000},"page":"244-255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nonreassuring fetal status during labor and offspring's childhood neurodevelopment at 3\u2009years of age: The Japan Environment and Children's Study"],"prefix":"10.1002","volume":"165","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9506-117X","authenticated-orcid":false,"given":"Tsuyoshi","family":"Murata","sequence":"first","affiliation":[{"name":"Fukushima Regional Center for the Japan Environment and Children's Study  Fukushima Japan"},{"name":"Department of Obstetrics and Gynecology Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo","family":"Kyozuka","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environment and Children's Study  Fukushima Japan"},{"name":"Department of Obstetrics and Gynecology Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environment and Children's Study  Fukushima Japan"},{"name":"Department of Obstetrics and Gynecology Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Imaizumi","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environment and Children's Study  Fukushima Japan"},{"name":"Department of Obstetrics and Gynecology Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotaka","family":"Isogami","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environment and Children's Study  Fukushima Japan"},{"name":"Department of Obstetrics and Gynecology Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toma","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environment and Children's Study  Fukushima Japan"},{"name":"Department of Obstetrics and Gynecology Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environment and Children's Study  Fukushima Japan"},{"name":"Department of Obstetrics and Gynecology Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Sato","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environment and Children's Study  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Ogata","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environment and Children's Study  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosei","family":"Shinoki","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environment and Children's Study  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuaki","family":"Hosoya","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environment and Children's Study  Fukushima Japan"},{"name":"Department of Pediatrics Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Yasumura","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environment and Children's Study  Fukushima Japan"},{"name":"Department of Public Health Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environment and Children's Study  Fukushima Japan"},{"name":"Department of Pediatrics Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiya","family":"Fujimori","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environment and Children's Study  Fukushima Japan"},{"name":"Department of Obstetrics and Gynecology Fukushima Medical University School of Medicine  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Nishigori","sequence":"additional","affiliation":[{"name":"Fukushima Regional Center for the Japan Environment and Children's Study  Fukushima Japan"},{"name":"Fukushima Medical Center for Children and Women Fukushima Medical University  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The Japan Environment and Children's Study (JECS) Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001108"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-021-04249-y"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/birt.12527"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2017-314034"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182004fa9"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2021.1929111"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(69)90008-8"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(71)90341-3"},{"key":"e_1_2_11_10_1","first-page":"149","article-title":"Epidemiological principles for the evaluation of monitoring programs\u2014the Dublin experience","volume":"16","author":"Grant A","year":"1993","journal-title":"Clin Invest Med"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0264117"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(82)90051-2"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-1036"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199603073341001"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-14-25"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20170018"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2010.01342.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.13990"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-3313"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20150064"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.12331"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10803"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-021-04294-z"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2011.01653.x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.04.026"},{"key":"e_1_2_11_26_1","article-title":"Acute tocolysis for uterine tachysystole or suspected fetal distress","volume":"7","author":"Leathersich SJ","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58091218"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpr.257"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2005.01403.x"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-021-03972-6"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31930-5"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14668"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-34231-y"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67856-z"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148122"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.15206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T15:29:19Z","timestamp":1720193359000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.15206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,20]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/ijgo.15206"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.15206","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"type":"print","value":"0020-7292"},{"type":"electronic","value":"1879-3479"}],"subject":[],"published":{"date-parts":[[2023,11,20]]},"assertion":[{"value":"2023-06-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}