{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T02:11:51Z","timestamp":1782439911678,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T00:00:00Z","timestamp":1699747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To estimate the rate and risk factors of re\u2010intervention for patients with uterine fibroids (UFs) undergoing high\u2010intensity focused ultrasound (HIFU) at different age distributions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective cohort study was conducted in Nanchong Central Hospital, recruiting a total of 672 patients with UFs undergoing HIFU from June 2017 to December 2019. Using univariate and multivariate logistic regression, risk factors for re\u2010intervention were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 401 patients with UFs who completed the follow\u2010up visits (median 47\u2009months, range 34\u201361), 50 (12.46%) patients underwent re\u2010intervention (such as high\u2010intensity focused ultrasound, uterine artery embolization, myomectomy and hysterectomy). In the different age distributions, the re\u2010intervention rate was 17.5% (34\/194) in patients aged &lt;45\u2009years and 7.7% (16\/207) in those aged \u226545\u2009years. Regarding the younger patient group (aged &lt;45\u2009years), hypo\u2010 or iso\u2010intensive fibroids in T2\u2010weighted magnetic resonance imaging (T2WI) intensity may elevate the risk of re\u2010intervention for UFs (odds ratio [OR] 2.96, 95% confidence interval [CI] 1.37\u20136.62; <jats:italic>P<\/jats:italic>\u2009=\u20090.007). Among the older patient group (aged \u226545\u2009years), preoperative anemic patients had an increased risk of re\u2010intervention compared with those without anemia (OR 3.30, 95% CI 1.01\u201310.37; <jats:italic>P<\/jats:italic>\u2009=\u20090.041).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The re\u2010intervention rate of HIFU decreased with increasing age. Among those aged &lt;45\u2009years, T2WI intensity was the independent risk factor for re\u2010intervention, and among those aged \u226545\u2009years, preoperative anemic status may be related to re\u2010intervention outcome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15217","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T01:37:46Z","timestamp":1699839466000},"page":"1212-1219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Age\u2010stratified risk factors of re\u2010intervention for uterine fibroids treated with high\u2010intensity focused ultrasound"],"prefix":"10.1002","volume":"164","author":[{"given":"Neng\u2010huan","family":"Tang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ultrasound in Medicine and Engineering College of Biomedical Engineering, Chongqing Medical University  Chongqing People's Republic of China"},{"name":"Department of Obstetrics and Gynecology Affiliated Nanchong Central Hospital of North Sichuan Medical University  Nanchong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010ling","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Affiliated Nanchong Central Hospital of North Sichuan Medical University  Nanchong People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010hao","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ultrasound in Medicine and Engineering College of Biomedical Engineering, Chongqing Medical University  Chongqing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Affiliated Nanchong Central Hospital of North Sichuan Medical University  Nanchong 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