{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:13:41Z","timestamp":1791828821687,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T00:00:00Z","timestamp":1699142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy and safety of non\u2010ablative vaginal Er:YAG laser device in stress urinary incontinence (SUI) treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a multicenter blinded randomized sham\u2010controlled trial in which women with urodynamic SUI were randomization to active arm using Er:YAG laser therapy, and sham arm using sham handpiece. Patients received two treatments 1\u2009month apart. The primary outcomes measure was 1\u2009h pad weight test measured at 6\u2009months. Secondary outcomes were durability of treatment success at 12\u2009months, and questionnaires for assessment of SUI severity (ICIQ\u2010UI SF), sexual function (PISQ\u201012) and HRQoL (KHQ), and incidence and severity of device related adverse events and pain (VAS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 110 participants with SUI were recruited; 73 in the active arm and 37 in the sham arm. Two participants were excluded; one was assigned the wrong treatment and one withdrew their consent. Treatment success was observed in 36% of the sham arm and 59% of the active arm; in the latter, odds of achieving treatment success were more than three\u2010fold higher (OR 3.63, 95% CI: 1.3\u201311.2, <jats:italic>P<\/jats:italic>\u2009=\u20090.02). HRQoL by KHQ showed significant improvement in the active versus the sham arm (OR 0.36, 95% CI: 0.15\u20130.87, <jats:italic>P<\/jats:italic>\u2009=\u20090.003). Similarly, subjective patient assessment of general and sexual function improvement with PISQ\u201012 and PGI\u2010I showed superior effect over sham (OR 2.8, 95% CI: 1.2\u20137.0, <jats:italic>P<\/jats:italic>\u2009=\u20090.02 and OR 0.13, 95% CI: 0.05\u20130.36, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Non\u2010ablative vaginal Er:YAG laser therapy significantly improves SUI symptoms versus sham treatment. Er:YAG laser therapy should be considered as a non\u2010surgical treatment option for SUI patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15222","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T02:16:59Z","timestamp":1699237019000},"page":"1184-1194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Vaginal erbium laser treatment for stress urinary incontinence: A multicenter randomized sham\u2010controlled clinical trial"],"prefix":"10.1002","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4031-9414","authenticated-orcid":false,"given":"Barry A.","family":"O'Reilly","sequence":"first","affiliation":[{"name":"Department of Urogynecology Cork University Maternity Hospital  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Viereck","sequence":"additional","affiliation":[{"name":"Bladder and Pelvic Floor 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