{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:42:01Z","timestamp":1792424521450,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the outcomes associated with each therapeutic option for patients diagnosed with interstitial pregnancy (IP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a multicentric retrospective cohort study within the departments of Gynecology and Obstetrics involved in the Francogent research group. Women treated for an interstitial pregnancy between January 2008 to December 2019 were included. Three therapeutic options were evaluated: surgical treatment (ST); in\u00a0situ methotrexate combined with systemic methotrexate (IS\u2010MTX); and systemic methotrexate (IM\u2010MTX). Success of first\u2010line treatment was defined by hCG negativation (&lt;5I\u2009U\/L). Secondary outcomes included the need for secondary surgical procedure, secondary medical treatment, emergency surgery, postoperative complications, duration of hospitalization, and delay before hCG negativation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 98 patients were managed for IP: 42 (42.9%) patients had IM\u2010MTX; 34 (34.7%) had IS\u2010MTX; and 22 (22.4%) had ST. First\u2010line treatment was successful in all patients of the ST group (22\/22, 100%), in 31% of patients within the IM\u2010MTX group (13\/42) and 70.6% (24\/34) in the IS\u2010MTX group. The sole parameter associated with the risk of treatment failure was the mode of methotrexate administration. The size of the gestational sac or the presence of fetal heartbeat was not associated with decreased medical treatment (IS or IM\u2013MTX) efficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Either ST or IS\u2010MTX are good options for IP treatment associated with high success rates. A single\u2010dose regimen of IM\u2010MTX is less efficient than IS\u2010MTX or ST. Symptomatic patients with severity criteria should always undergo emergency surgery. IP remains a high\u2010risk condition that should be managed, whenever possible, in referral centers to potentialize the chances of favorable outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15239","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T09:07:09Z","timestamp":1699434429000},"page":"125-130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Interstitial pregnancy management: A multicentric analysis of 98 patients from the FRANCOGENT group comparing surgery and medical treatment"],"prefix":"10.1002","volume":"165","author":[{"given":"Thomas","family":"Dabreteau","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology CHI Creteil  Creteil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Puchar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tenon Hospital, 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