{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:08:57Z","timestamp":1719187737342},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To what extent traditional Chinese medicine (TCM) combined with mifepristone and misoprostol is beneficial for improving the complete abortion rate and duration of vaginal bleeding has been a subject of debate in the field of medical abortion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the evidence regarding the complete abortion rate and duration of vaginal bleeding of medical abortion assisted by different kinds of TCM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search Strategy<\/jats:title><jats:p>We searched electronic databases such as PubMed, Web of Science and Cochrane Library database, China National Knowledge Internet, Wan fang Database, VIP Database, and China Biology Medicine disc from 2000 to February 15, 2023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection Criteria<\/jats:title><jats:p>The control group was medical abortion with mifepristone and misoprostol, and the experimental group was medical abortion assisted by TCM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Collection and Analysis<\/jats:title><jats:p>Major data extraction included sample size, age, medicine used for abortion, outcome measures. RevMan 5.3 and Stata 15.1 software were used to assess the literature quality and perform network meta\u2010analysis, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Results<\/jats:title><jats:p>A total of 73 randomized controlled trials (RCTs) with 11\u2009683 patients and nine kinds of TCM were included in this study. Compared with mifepristone and misoprostol, eight kinds of TCM had statistical significance in improving the complete abortion rate. The effect value of Sancao decoction was 5.86 (95% confidence interval [CI] 2.53\u201313.58). Seven kinds of TCM shortened the duration of vaginal bleeding. The effect value of comfrey and trichosanthin decoction was \u22128.75 (95% CI \u201310.86 to \u22126.64).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This network meta\u2010analysis showed that Lenge Zhumo decoction and Sancao decoction could have a large beneficial effect on complete abortion rate in medical abortion during early pregnancy, and comfrey and trichosanthin decoction could be the best TCM for shortening the duration of vaginal bleeding.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15272","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T10:18:36Z","timestamp":1701425916000},"page":"152-162","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of medical abortion assisted by traditional Chinese medicine: A network meta\u2010analysis of randomized controlled trials"],"prefix":"10.1002","volume":"166","author":[{"given":"Fuxing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingru","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Obstetrics The First Hospital of Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Chinese Medicine The First Hospital of Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junni","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization.Abortion. Consequences of inaccessible quality abortion care. Accessed March 15 2022.https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/abortion"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003026"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(20)30315-6"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31794-4"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328313"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003017"},{"issue":"2","key":"e_1_2_10_8_1","first-page":"198","article-title":"Treatment strategies in the vaginal bleeding after drug abortion of integrated medicine","volume":"9","author":"Shi HY","year":"2017","journal-title":"China Contin Med Edu"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2007.12.009"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2005.11.008"},{"issue":"2","key":"e_1_2_10_11_1","first-page":"216","article-title":"Experimental research progress on the mechanism of traditional Chinese medicine intervention in medical abortion","volume":"30","author":"Chen PD","year":"2021","journal-title":"Mod. J. Integr. Tradit. Chin. West. Med"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2018.11.002"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-020-01003-8"},{"issue":"11","key":"e_1_2_10_14_1","first-page":"Cd002855","article-title":"Medical methods for first trimester abortion","volume":"2011","author":"Kulier R","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12608"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2016.04.005"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15684"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2019.11.008"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000897"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2012.06.011"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.5811\/westjem.2022.8.57929"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(12)60003-4"},{"issue":"6","key":"e_1_2_10_23_1","first-page":"685","article-title":"Effect of Daoqi Tongjing needling method on intra\u2010uterine residue after drug abortion from the perspectives of Hegu (LI 4) and Sanyinjiao (SP 6)","volume":"42","author":"Fan JQ","year":"2022","journal-title":"Zhongguo Zhen Jiu"},{"issue":"3","key":"e_1_2_10_24_1","first-page":"32","article-title":"Traditional Chinese medicine Quyu decoction combined with conventional medical abortion to reduce the incomplete rate of abortion","volume":"30","author":"Zheng SY","year":"2020","journal-title":"Shenzhen J. Integr. Tradit. Chin. West. Med"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m3907"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2011.01.012"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099682"},{"issue":"11","key":"e_1_2_10_28_1","first-page":"1284","article-title":"Advances in methodology of network meta\u2010analysis (18): GRADE evidence certainty in Network MetaAnalysis","volume":"13","author":"Wu SS","year":"2021","journal-title":"Chin J Evid\u2010Based Med Cardiovasc Med"},{"issue":"1","key":"e_1_2_10_29_1","first-page":"1","article-title":"Advances in methodology of network meta\u2010analysis (20): sample size calculation and precision assessment in network meta\u2010analysis","volume":"14","author":"Yang ZR","year":"2022","journal-title":"Chin J Evid\u2010Based Med Cardiovasc Med"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2011.01.011"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.8166"},{"issue":"41","key":"e_1_2_10_32_1","first-page":"3255","article-title":"Effect of short\u2010acting combined oral contraceptives on bleeding after induced abortion","volume":"97","author":"Wang XF","year":"2017","journal-title":"Nat Med J China"},{"issue":"15","key":"e_1_2_10_33_1","first-page":"3990","article-title":"Systematic review and meta\u2010analysis on efficacy and safety of Gongxuening capsules in treatment of abnormal vaginal bleeding after medical abortion","volume":"46","author":"Niu BH","year":"2021","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"issue":"7","key":"e_1_2_10_34_1","first-page":"848","article-title":"Systematic review of intervention effects of Xinshenghua granules on mifepristone combined with misoprostol for early medical abortion","volume":"21","author":"Hu NN","year":"2021","journal-title":"Eval. Anal. Drug\u2010Use Hosp. China"},{"issue":"1","key":"e_1_2_10_35_1","first-page":"177","article-title":"Advances in studies on medicinal Arnebiae radix","volume":"23","author":"Ma SJ","year":"2021","journal-title":"Mod Chin Med"},{"issue":"23","key":"e_1_2_10_36_1","first-page":"60","article-title":"History of Chinese herbs in terminating pregnancy","volume":"29","author":"Xu XM","year":"2020","journal-title":"Chinese J Ethnomedicine Ethnopharmacy"},{"key":"e_1_2_10_37_1","first-page":"8","article-title":"AFM study on the damage effect of trichosanthin on red blood cells","volume":"02","author":"Zhao T","year":"2003","journal-title":"Biotechnology"},{"key":"e_1_2_10_38_1","first-page":"1","article-title":"Chemical constituents and pharmacological activities of trichosanthin","volume":"01","author":"Li ZH","year":"2003","journal-title":"Drugs & Clinic"},{"issue":"6","key":"e_1_2_10_39_1","first-page":"118","article-title":"Research progress on chemical constituents pharmacological action and clinical application of Aromae","volume":"24","author":"Chen WP","year":"2022","journal-title":"J Liaoning Univ Tradit Chin Med"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.4103\/jehp.jehp_1274_21"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsb1612526"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2019.06.004"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.15272","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T07:04:04Z","timestamp":1719126244000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.15272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/ijgo.15272"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.15272","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"2023-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}