{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:27:23Z","timestamp":1787959643842,"version":"build-2784847793"},"reference-count":82,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous reviews on hysterectomy versus uterine\u2010sparing surgery in pelvic organ prolapse (POP) repair did not consider that the open abdominal approach or transvaginal mesh use have been largely abandoned.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To provide up\u2010to\u2010date evidence by examining only studies investigating techniques currently in use for POP repair.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search Strategy<\/jats:title><jats:p>MEDLINE and Embase databases were searched from inception to January 2023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection Criteria<\/jats:title><jats:p>We included randomized and non\u2010randomized studies comparing surgical procedures for POP with or without concomitant hysterectomy. Studies describing open abdominal approaches or transvaginal mesh implantation were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Collection and Analysis<\/jats:title><jats:p>A random effect meta\u2010analysis was conducted on extracted data reporting pooled mean differences and odds ratios (OR) between groups with 95% confidence intervals (CI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Results<\/jats:title><jats:p>Thirty\u2010eight studies were included. Hysterectomy and uterine\u2010sparing procedures did not differ in reoperation rate (OR 0.93; 95% CI 0.74\u20131.17), intraoperative major (OR 1.34; 95% CI 0.79\u20132.26) and minor (OR 1.38; 95% CI 0.79\u20132.4) complications, postoperative major (OR 1.42; 95% CI 0.85\u20132.37) and minor (OR 1.18; 95% CI 0.9\u20131.53) complications, and objective (OR 1.38; 95% CI 0.92\u20132.07) or subjective (OR 1.23; 95% CI 0.8\u20131.88) success. Uterine preservation was associated with a shorter operative time (\u221222.7\u2009min; 95% CI \u201316.92 to \u221228.51\u2009min), shorter hospital stay (\u22120.35\u2009days, 95% CI \u20130.04 to \u22120.65\u2009days), and less blood loss (\u221261.7\u2009mL; 95% CI \u201331.3 to \u221292.1\u2009mL). When only studies using a laparoscopic approach for both arms were considered, no differences were observed in investigated outcomes between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No major differences were observed in POP outcomes between procedures with and without concomitant hysterectomy. The decision to preserve or remove the uterus should be tailored on individual factors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15343","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T10:42:10Z","timestamp":1706179330000},"page":"173-189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Clinician perspectives on hysterectomy versus uterine preservation in pelvic organ prolapse surgery: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"166","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0304-4274","authenticated-orcid":false,"given":"Irene","family":"Porcari","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, AOUI Verona University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0108-4942","authenticated-orcid":false,"given":"Pier Carlo","family":"Zorzato","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, AOUI Verona University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2109-6182","authenticated-orcid":false,"given":"Mariachiara","family":"Bosco","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, AOUI Verona University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5840-699X","authenticated-orcid":false,"given":"Simone","family":"Garzon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, AOUI Verona University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5989-6239","authenticated-orcid":false,"given":"Francesca","family":"Magni","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, AOUI Verona University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5773-7271","authenticated-orcid":false,"given":"Stefano","family":"Salvatore","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology IRCCS San Raffaele Scientific Institute, University Vita and Salute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7722-5553","authenticated-orcid":false,"given":"Massimo P.","family":"Franchi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, AOUI Verona University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4456-0822","authenticated-orcid":false,"given":"Stefano","family":"Uccella","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, AOUI Verona University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60462-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.11.1311"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000175832.13266.bb"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.07.038"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.04.046"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181985312"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.01.042"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001920170012"},{"issue":"441","key":"e_1_2_8_10_1","first-page":"e1","article-title":"Body image perceptions in women with pelvic organ prolapse: a qualitative study","volume":"204","author":"Lowder JL","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181c2ce96"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.114868"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(01)01472-7"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0000000000000200"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPV.0000000000001069"},{"key":"e_1_2_8_16_1","first-page":"CD004014","article-title":"Surgical management of pelvic organ prolapse in women","volume":"4","author":"Maher C","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0000000000000105"},{"key":"e_1_2_8_18_1","article-title":"Surgery for women with apical vaginal prolapse","volume":"10","author":"Maher C","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.01.018"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-017-3433-1"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2021.10.020"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-021-04913-9"},{"key":"e_1_2_8_23_1","unstructured":"FDA takes action to protect women's health orders manufacturers of surgical mesh intended for transvaginal repair of pelvic organ prolapse to stop selling all devices. FDA.2020. Accessed January 18 2023.https:\/\/www.fda.gov\/news\u2010events\/press\u2010announcements\/fda\u2010takes\u2010action\u2010protect\u2010womens\u2010health\u2010orders\u2010manufacturers\u2010surgical\u2010mesh\u2010intended\u2010transvaginal"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.08.035"},{"key":"e_1_2_8_25_1","first-page":"CD003677","article-title":"Surgical approach to hysterectomy for benign gynaecological disease","volume":"2015","author":"Aarts JWM","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-018-3755-7"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.10.009"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.5336\/medsci.2011-28041"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-009-1014-7"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l5149"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.4103\/GMIT.GMIT_126_19"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-021-04932-6"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001920170017"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-003-1084-x"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-005-1346-x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-009-0945-3"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-011-1422-3"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-011-1635-5"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2012.10.014"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2014.10.011"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12678"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-015-2775-9"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-016-3119-0"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2019.07.006"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-019-03950-9"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2019.02.012"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-019-04206-2"},{"key":"e_1_2_8_53_1","first-page":"5672","article-title":"A comparison of modified laparoscopic uterine suspension and vaginal hysterectomy with sacrospinous ligament fixation for treating pelvic organ prolapse","volume":"13","author":"Zhu H","year":"2021","journal-title":"Am J Transl Res"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-021-04865-0"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-018-3678-3"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-017-3519-9"},{"key":"e_1_2_8_57_1","first-page":"262","article-title":"Outcomes of laparoscopic hysteropexy and supracervical hysterectomy plus cervicopexy: a retrospective study","volume":"32","author":"Li P\u2010C","year":"2020","journal-title":"Ci Ji Yi Xue Za Zhi"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2020.02.017"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPV.0000000000000917"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-021-01208-5"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.4103\/GMIT.GMIT_127_20"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPV.0000000000001011"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-022-05240-3"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-022-05403-2"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2022.12.011"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.75"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2008.08.010"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22641"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-017-3405-5"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-020-04260-1"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.05.046"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2004.00001.x"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.12812"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-013-2177-9"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPV.0b013e318249bd54"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2007.11.006"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.01.029"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-021-04754-6"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPV.0000000000000794"},{"key":"e_1_2_8_80_1","unstructured":"Overview | Urinary incontinence and pelvic organ prolapse in women: management | Guidance | NICE. Accessed July 5 2022.https:\/\/www.nice.org.uk\/guidance\/ng123"},{"issue":"481","key":"e_1_2_8_81_1","first-page":"e1","article-title":"Prolapse\u2010related knowledge and attitudes toward the uterus in women with pelvic organ prolapse symptoms","volume":"209","author":"Good MM","year":"2013","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPV.0000000000001030"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.05.042"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.15343","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T07:05:26Z","timestamp":1719126326000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.15343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,25]]},"references-count":82,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/ijgo.15343"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.15343","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,25]]},"assertion":[{"value":"2023-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}