{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:58:41Z","timestamp":1792205921010,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To consider the classical use of \u201cpH\u2009&lt;\u20097.0 and\/or a base deficiency \u226512\u2009mmol\/L\u201d as markers of the risk of neonatal hypoxic\u2013ischemic encephalopathy (HIE), recalling various criticisms of the use of these markers in favor of that of neonatal eucapnic pH, which appears to be a better marker of this risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010five cases of acidemia with pH\u2009&lt;\u20097.00 were collected from a cohort from the Nice University Hospital with eight cases of HIE. We compared the receiver operating characteristics curves established from the positive likelihood ratio (+LR) for each case of: umbilical cord artery pH (pHa), neonatal eucapnic pH (pH euc\u2010n) in isolation (not matched to pHa), and matched pHa to its own pH euc\u2010n.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The areas under the curve (AUC) are identical for pHa and pH euc\u2010n, but AUC for the matched pair pHa\u2013pH euc\u2010n appears superior but non\u2010significant because of the small number in our cohort. However, using the bootstrap method, the partial AUC for a sensitivity greater than 75% indicates the significant superiority (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) of the matched pair pHa\u2013pH euc\u2010n approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The originality of this study lies in the use of two methodologic approaches: (1) standardized partial analysis of the AUCs of the pHa curve and that of pHa matched to its own pH euc\u2010n, and (2) bootstrap statistical technique, that allowed us to conclude (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) that the combined use of pH measured at the cord coupled with its eucapnic correction is better for diagnosing metabolic acidosis and best predicting the risk of HIE.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15350","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T09:44:03Z","timestamp":1704793443000},"page":"1114-1121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Eucapnic <scp>pH<\/scp> coupled with arterial cord <scp>pH<\/scp> improves hypoxic\u2013ischemic encephalopathy prediction"],"prefix":"10.1002","volume":"165","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5664-4337","authenticated-orcid":false,"given":"Pierre\u2010Alexis","family":"Gauci","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Reproduction and Fetal Medicine CHU de Nice University of C\u00f4te d'Azur  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Racinet","sequence":"additional","affiliation":[{"name":"RHEOP  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Ouellet","sequence":"additional","affiliation":[{"name":"Vitalit\u00e9 Health Network, Northwest zone, Adjunct Professor (Ret.), Department of Surgery Sherbrooke University  Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Daboval","sequence":"additional","affiliation":[{"name":"Department of Neonatology Ottawa University  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio Eleni dit","family":"Trolli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Reproduction and Fetal Medicine CHU de Nice University of C\u00f4te d'Azur  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Delotte","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Reproduction and Fetal Medicine CHU de Nice University of C\u00f4te d'Azur  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.05.010"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2014.3269"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-0899"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-018-1232-6"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.02.035"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gyobfe.2016.04.005"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181e7d267"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/pch\/pxy028"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0412.2011.01241.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0412.2011.01364.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.12.026"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2019.1685966"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(03)00574-X"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000220544.21316.80"},{"key":"e_1_2_9_16_1","unstructured":"EttoriC RacinetC ArnouldP et\u00a0al.Imputabilit\u00e9 de l'asphyxie f\u0153tale perpartum dans la paralysie c\u00e9r\u00e9brale infantile. 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