{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:14:44Z","timestamp":1747149284604,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002842","name":"Chiang Mai University","doi-asserted-by":"publisher","award":["CMU\u20102566"],"award-info":[{"award-number":["CMU\u20102566"]}],"id":[{"id":"10.13039\/501100002842","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare obstetric outcomes between women with \u03b2\u2010thalassemia\/hemoglobin E (\u03b2\u2010thal\/HbE) disease and those of low\u2010risk pregnancies, and also between the two subgroups, \u03b2\u2010thal<jats:sup>0<\/jats:sup>\/HbE and \u03b2\u2010thal<jats:sup>+<\/jats:sup>\/HbE disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study was undertaken on pregnant women with \u03b2\u2010thal\/HbE disease and low\u2010risk pregnancies, which were randomly selected with a case\u2010to\u2010control ratio of 1:10.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pregnancies with \u03b2\u2010thal\/HbE disease were identified in 0.19% of 59\u2009152 pregnancies, including 104 women in the study group and 1040 women in the control group. The mean gestational age and mean birth weight were significantly lower in the study group. The prevalence of fetal growth restriction, preterm birth and low birth weight were significantly increased in the study group based on both univariate and multivariate analysis. The impacts were more striking in the \u03b2\u2010thal<jats:sup>0<\/jats:sup>\/HbE subgroup than in the \u03b2\u2010thal<jats:sup>+<\/jats:sup>\/HbE subgroup. The cesarean rate was significantly higher in the study group. No maternal death or serious complication was found in this cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on this cohort, the largest ever published, \u03b2\u2010thal\/HbE disease is significantly associated with increased incidence of fetal growth restriction, preterm birth and low birth weight. The impacts were more pronounced in the \u03b2\u2010thal<jats:sup>0<\/jats:sup>\/HbE subgroup. Pregnancy may be relatively safer for women with \u03b2\u2010thal\/HbE disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15360","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T06:54:26Z","timestamp":1705560866000},"page":"360-367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impacts of \u03b2\u2010thalassemia\/hemoglobin E disease on pregnancy outcomes"],"prefix":"10.1002","volume":"166","author":[{"given":"Puntira","family":"Anuruksuwan","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirinart","family":"Sirilert","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suchaya","family":"Luewan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3389-6478","authenticated-orcid":false,"given":"Theera","family":"Tongsong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a011734"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05579.x"},{"key":"e_1_2_10_4_1","first-page":"493","article-title":"The inherited disorders of haemoglobin: an increasingly neglected global health burden","volume":"134","author":"Weatherall D","year":"2011","journal-title":"Indian J Med Res"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.06.036673"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)08246-X"},{"key":"e_1_2_10_7_1","first-page":"704","article-title":"Inherited haemoglobin disorders: an increasing global health problem","volume":"79","author":"Weatherall DJ","year":"2001","journal-title":"Bull World Health Organ"},{"key":"e_1_2_10_8_1","first-page":"522","article-title":"Hb E\/beta\u2010thalassaemia: a common & clinically diverse disorder","volume":"134","author":"Olivieri NF","year":"2011","journal-title":"Indian J Med Res"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-200203000-00007"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-019-01176-9"},{"key":"e_1_2_10_11_1","first-page":"58","article-title":"Thalassemia intermedia","volume":"80","author":"Camaschella C","year":"1995","journal-title":"Haematologica"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199907083410207"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1345.062"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(02)00225-4"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2008.10.012"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1995.tb11400.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2005.02.015"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(00)00982-0"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-199402000-00025"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(97)00089-4"}],"container-title":["International Journal of Gynecology &amp; 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