{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:05:11Z","timestamp":1772989511010,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare two cancellation policies in controlled ovarian stimulation\u2010intrauterine insemination (COS\u2010IUI) cycles to lower the risk of multiple pregnancies (MP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>We performed a bicentric retrospective cohort study in two academic medical centers: Angers (group A) and Besan\u00e7on (group B) University Hospitals. We included 7056 COS\u2010IUI cycles between 2011 and 2019. In group A, cancellation strategy was based on an algorithm taking into account the woman's age, the serum estradiol level, and the number of follicles of 14\u2009mm or greater on ovulation trigger day. In group B, cancellation strategy was case\u2010by\u2010case and physician\u2010dependent, based on the woman's age, number of follicles of 15\u2009mm or greater, and the previous number of failed COS\u2010IUI cycles, without any predefined cut\u2010off. Our main outcome measures were the MP rate (MPR) and the live\u2010birth rate (LBR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 884 clinical pregnancies (790 singletons, 86 twins, and 8 triplets) obtained from 6582 COS\u2010IUI cycles. MPR was significantly lower in group A compared with group B (8.1% vs 13.3%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01), but LBR were comparable (10.8% vs 11.8%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.19). Multivariate logistic regression found the following to be risk factors for MP: the \u201ccancellation strategy\u201d effect (adjusted odds ratio [aOR] 1.63, 95% confidence interval [CI] 1.02\u20132.60) and the number of follicles of 14\u2009mm or greater (aOR 1.39, 95% CI 1.16\u20131.66). Cycle cancellation rate for excessive response was significantly lower in group A compared with group B (1.3% vs 2.4%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The use of an algorithm based on the woman's age, serum estradiol level and number of follicles of at least 14\u2009mm on trigger day allows the MPR to be reduced without impacting the LBR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.15449","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T02:44:15Z","timestamp":1709261055000},"page":"692-698","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of two cancellation strategies to lower the risk of multiple pregnancies in gonadotropin stimulated intrauterine insemination cycles"],"prefix":"10.1002","volume":"166","author":[{"given":"Aur\u00e9lie","family":"Berdin","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine Besan\u00e7on University Hospital  Besan\u00e7on France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Bella\u00efche","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Angers University Hospital  Angers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hady","family":"El\u00a0Hachem","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Lebanese American University Medical Center  Beirut Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Vielle","sequence":"additional","affiliation":[{"name":"Clinical Research Center Angers University Hospital  Angers 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France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4568-1746","authenticated-orcid":false,"given":"Pierre\u2010Emmanuel","family":"Bouet","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Angers University Hospital  Angers France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)45308-2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2013.01.017"},{"issue":"17","key":"e_1_2_9_4_1","first-page":"3260","article-title":"Results generated from European registers by ESHRE","volume":"2002","author":"Nygren KG","year":"1999","journal-title":"Hum 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