{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T13:41:30Z","timestamp":1776692490983,"version":"3.51.2"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T00:00:00Z","timestamp":1711670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T00:00:00Z","timestamp":1711670400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008323","name":"Zanjan University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008323","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2024,8]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n Cervical ectropion occurs due to the eversion of the endocervix that exposes glandular cells to the vaginal milieu. The aim of the present study was to evaluate and compare the clinical efficacy of effervescent vaginal tablets of tranexamic acid and cryotherapy in women with symptomatic cervical ectopy.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The current randomized clinical trial was conducted on 92 samples of women with cervical erosive ectropion from March 20, 2022 to August 27, 2022. Participants were divided into two groups; the intervention group (\n n<\/jats:italic>\n \u2009=\u200946) was treated with a 400\u2009mg effervescent vaginal tablet of tranexamic acid and the control group (\n n<\/jats:italic>\n \u2009=\u200946) underwent cryotherapy. All the patients were requested to visit weekly in the first month and then monthly for the next 3\u2009months, and the outcomes encompass improvement of symptoms (leukorrhea, dyspareunia, pelvic pain, post\u2010coital bleeding, and suprapubic pain) and cervical erosive ectropion view were monitored based on repeated examinations.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In this study, no statistically significant difference was observed in cure rate of symptoms between study groups (\n P<\/jats:italic>\n value\u2009>\u20090.05). Women in both the tranexamic acid and cryotherapy groups reported significant improvements in dyspareunia (34 [75%] vs 31 [67%]), pelvic pain (34 [75%] vs 34 [74%]), post\u2010coital bleeding (37 [81%] vs 31 [67%]), leukorrhea (36 [78%] vs 36 [78%]), suprapubic pain (32 [71%] vs 33 [73%]) disappearance of cervical ectropion tranexamic acid (40 [86%], vs 39 [84%]).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Our findings highlighted the equal effect of tranexamic acid and cryotherapy for treating cervical ectropion. Due to the ease of use, availability, and fewer side effects of tranexamic acid, it can be a suitable alternative to cryotherapy.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n \n IRCT20220115053719N1. The name of the registry: Iranian Registry of Clinical Trials. URL of registration:\n https:\/\/en.irct.ir\/trial\/61483<\/jats:ext-link>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ijgo.15458","type":"journal-article","created":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T04:29:40Z","timestamp":1711686580000},"page":"727-734","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Could tranexamic acid be a suitable alternative to cryotherapy for symptomatic cervical ectopy? Results from a randomized clinical trial"],"prefix":"10.1002","volume":"166","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8117-5176","authenticated-orcid":false,"given":"Shabnam","family":"Tofighi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Mosavi Hospital Zanjan University of Medical Sciences Zanjan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8937-5401","authenticated-orcid":false,"given":"Farzaneh","family":"Hekmatfar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Mosavi Hospital Zanjan University of Medical Sciences Zanjan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1406-8634","authenticated-orcid":false,"given":"Mahdi","family":"Tavakolizadeh","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, School of Pharmacy Zanjan University of Medical Sciences Zanjan 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