{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:49:37Z","timestamp":1787701777057,"version":"build-2784847793"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Mycoplasma genitalium<\/jats:italic> is an emerging pathogen, which has been linked to cervicitis, urethritis and pelvic inflammatory disease (PID). With the advent of multiplex polymerase chain reaction (PCR) panels for sexually transmitted infections, it is increasingly being identified in pregnant women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim was to review international guidelines, which had explicit recommendations for treatment of <jats:italic>M. genitalium<\/jats:italic> infection in pregnancy and breastfeeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search Strategy<\/jats:title><jats:p>PubMed, EMBASE and Cochrane databases were reviewed with no age, species, language or date restrictions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection Criteria<\/jats:title><jats:p>Studies were included if they had an explicit recommendation for treatment of <jats:italic>M. genitalium<\/jats:italic> in pregnancy. Studies were excluded if there was no recommendation in pregnancy, if they referred to other international guideline recommendations or were historical versions of guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Collection and Analysis<\/jats:title><jats:p>References were manually reviewed and 50 papers were selected for review. Only four guidelines were included in the final analysis and they were from Europe, <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>, Australia and Aotearoa New Zealand.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Results<\/jats:title><jats:p>All studies recommended azithromycin as first\u2010line treatment, and advised against moxifloxacin use. The dosing schedule of azithromycin, varied between guidelines, as did the utility\/safety of pristinamycin for macrolide resistant infections. Safety data was generally reassuring for azithromycin but inconsistent for pristinamycin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Azithromycin is the first\u2010line treatment for macrolide susceptible or unknown resistance infections, but there is a lack of consistency regarding dosing of azithromycin or the utility\/safety of pristinamycin for macrolide resistant infections in pregnancy\/lactation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15469","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T07:27:31Z","timestamp":1710574051000},"page":"27-34","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Treatment of <i>Mycoplasma genitalium<\/i> infection in pregnancy: A\u00a0systematic review of international guidelines"],"prefix":"10.1002","volume":"166","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9797-3797","authenticated-orcid":false,"given":"Richard J.","family":"Drew","sequence":"first","affiliation":[{"name":"Clinical Innovation Unit Rotunda Hospital  Dublin Ireland"},{"name":"Irish Meningitis and Sepsis Reference Laboratory Children's Health Ireland at Temple Street  Dublin Ireland"},{"name":"Department of Clinical Microbiology Royal College of Surgeons in Ireland  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maeve","family":"Eogan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Rotunda Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,15]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"277","article-title":"The clinical indications for testing women for Mycoplasma genitalium","volume":"98","author":"Latimer RL","year":"2022","journal-title":"Sex Transm Infect"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02304-21"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/09564624211030040"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/lam.13520"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.13609"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.859732"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2021-055352"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2016-0111"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/lambio\/ovac002","article-title":"Comparison of Seegene AnyPlexTM II STI\u20107e with standard\u2010of\u2010care diagnostic methods for the detection of Mycoplasma genitalium, Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis","volume":"76","author":"Bodiybadu K","year":"2023","journal-title":"Lett Appl Microbiol"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0282439"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12051141"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2022.08.009"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06910-1"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17972"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11030353"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19067"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaa291"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000001415"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2402.170902"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_9_22_1","unstructured":"British Association of Sexual Health and HIV.Mycoplasma genitalium.2023. Accessed May 26 2023.https:\/\/www.bashhguidelines.org\/current\u2010guidelines\/urethritis\u2010and\u2010cervicitis\/mycoplasma\u2010genitalium\u20102018\/"},{"key":"e_1_2_9_23_1","unstructured":"Australian STI Management Guidelines for use in Primary Care.Mycoplasma genitalium.2022. Accessed May 26 2023.https:\/\/sti.guidelines.org.au\/sexually\u2010transmissible\u2010infections\/mycoplasma\u2010genitalium\/"},{"key":"e_1_2_9_24_1","unstructured":"Aotearoa New Zealand STI Management Guidelines for use in Primary Care.Mycoplasma genitalium.2023. 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