{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:18:42Z","timestamp":1790180322193,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010414","name":"Health Research Board","doi-asserted-by":"publisher","award":["PRPG\/H\/18\/325"],"award-info":[{"award-number":["PRPG\/H\/18\/325"]}],"id":[{"id":"10.13039\/100010414","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of the present study was to investigate associations between lifetime breastfeeding behaviors and cardiovascular risk in later reproductive years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This was a prospective 10\u2010year longitudinal cohort study of 168 parous women. Health, lifestyle and infant feeding questionnaires, blood samples, anthropometry and body composition were collected. Cardiovascular risk was estimated using QRISK\u00ae3 and hierarchical multiple linear regression analysis performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age was 42.4\u2009years (SD 3.8; range 31\u201350) and 98.7% (<jats:italic>n<\/jats:italic>\u2009=\u2009156\/158) were premenopausal. Ever breastfeeding rates were 72.6% (<jats:italic>n<\/jats:italic>\u2009=\u2009122\/168) and 37.5% (<jats:italic>n<\/jats:italic>\u2009=\u200963\/168) lifetime \u226512\u2009months breastfeeding duration. Median durations were 5.5\u2009weeks for exclusive breastfeeding (IQR 35.8; range 0\u2013190) and 30.5\u2009weeks for any breastfeeding (IQR 84.0; range 0\u2013488). Breastfeeding duration was not associated with QRISK\u00ae3 scores in adjusted models. Lower glycoprotein acetyls were associated with ever breastfeeding (<jats:italic>P<\/jats:italic>\u2009=\u20090.03), and lifetime breastfeeding \u226512\u2009months (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). Lifetime breastfeeding \u226512\u2009months and longer exclusive breastfeeding were associated with lower fat mass index (<jats:italic>P<\/jats:italic>\u2009=\u20090.03, <jats:italic>P<\/jats:italic>\u2009=\u20090.01), tissue percentage fat (<jats:italic>P<\/jats:italic>\u2009=\u20090.02, <jats:italic>P<\/jats:italic>\u2009=\u20090.009) and visceral adipose tissue volume (<jats:italic>P<\/jats:italic>\u2009=\u20090.04, <jats:italic>P<\/jats:italic>\u2009=\u20090.025) after correcting for confounders including body mass index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Longer breastfeeding is associated with favorable body composition and lower glycoprotein acetyls, a novel inflammatory biomarker associated with cardiometabolic risk. Breastfeeding is a low\u2010cost, health promoting behavior for women and infants. Pregnant women, especially those at higher risk of cardiovascular disease, should be counseled about the potential benefits of exclusive and longer breastfeeding duration.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15484","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T09:43:28Z","timestamp":1712569408000},"page":"1057-1067","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Breastfeeding duration is associated with favorable body composition and lower glycoprotein acetyls in later life"],"prefix":"10.1002","volume":"166","author":[{"given":"Catherine","family":"McNestry","sequence":"first","affiliation":[{"name":"Perinatal Research Center, University College Dublin National Maternity Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel K.","family":"Crowley","sequence":"additional","affiliation":[{"name":"Department of Endocrinology St\u00a0Vincent's University Hospital  Dublin Ireland"},{"name":"School of Medicine University College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharleen L.","family":"O'Reilly","sequence":"additional","affiliation":[{"name":"School of Agriculture and Food Science University College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Kasemiire","sequence":"additional","affiliation":[{"name":"Center for Support and Training in Analysis and Research University College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Callanan","sequence":"additional","affiliation":[{"name":"Perinatal Research Center, University College Dublin National Maternity Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Delahunt","sequence":"additional","affiliation":[{"name":"Perinatal Research Center, University College Dublin National Maternity Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Twomey","sequence":"additional","affiliation":[{"name":"School of Medicine University College Dublin  Dublin Ireland"},{"name":"Department of Clinical Chemistry St.\u00a0Vincent's University Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3477-6494","authenticated-orcid":false,"given":"Fionnuala M.","family":"McAuliffe","sequence":"additional","affiliation":[{"name":"Perinatal Research Center, University College Dublin National Maternity Hospital  Dublin Ireland"},{"name":"School of Medicine University College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,8]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"World Health Organsation.Global health estimates: Leading causes of death. 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