{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T10:13:25Z","timestamp":1767867205084,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T00:00:00Z","timestamp":1712275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Despite its widespread use, in\u00a0vitro fertilization (IVF) outcomes are challenged by implantation failure, largely due to factors such as embryo quality and endometrial receptivity. In this study, we investigated the clinical effect of office hysteroscopy (OH) on the subsequent frozen\u2013thawed embryo transfer (FET) in infertile women who experienced a failed IVF\u2013embryo transfer (IVF\u2010ET) cycle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 577 infertile women who underwent OH because of a history of failed ET between October 2019 and September 2021. During OH, visible endometrial polyps (EPs) were diagnosed and removed by curette or biopsy forceps; chronic endometritis (CE) was diagnosed by histopathology and immunohistochemistry and treated with oral doxycycline (0.2\u2009g\/d) for 14\u2009days. According to the hysteroscopic findings and endometrial pathology with immunohistochemistry, patients were divided into three groups: group A (<jats:italic>n<\/jats:italic>\u2009=\u2009161) had CE with or without EPs, group B (<jats:italic>n<\/jats:italic>\u2009=\u2009156) had EPs only, and group C (<jats:italic>n<\/jats:italic>\u2009=\u2009260) had no CE or EPs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the following FET cycle, the implantation rates were 47%, 51%, and 45% (<jats:italic>P<\/jats:italic>\u2009=\u20090.411); the clinical pregnancy rates were 56%, 62%, and 55% (<jats:italic>P<\/jats:italic>\u2009=\u20090.436); the live birth rates were 45%, 51%, and 42% (<jats:italic>P<\/jats:italic>\u2009=\u20090.205); and the miscarriage rates were 18%, 16%, and 22% (<jats:italic>P<\/jats:italic>\u2009=\u20090.497) in groups A, B, and C, respectively. There were no significant differences among groups (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>OH is helpful for diagnosis and treatment of abnormal intrauterine environment in women with a failed IVF cycle and further improves their pregnancy outcome in the following FET.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15522","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T13:04:38Z","timestamp":1712322278000},"page":"1345-1350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical utility of office hysteroscopy following failed in\u00a0vitro fertilization\u2013embryo transfer: A retrospective cohort study"],"prefix":"10.1002","volume":"166","author":[{"given":"Hanyun","family":"Zhang","sequence":"first","affiliation":[{"name":"Division of Reproductive Medicine West\u00a0China Second University Hospital of Sichuan University  Chengdu China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education  Chengdu China"},{"name":"NHC Key Laboratory of Chronobiology of Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukanxuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Reproductive Medicine West\u00a0China Second University Hospital of Sichuan University  Chengdu China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education  Chengdu China"},{"name":"NHC Key Laboratory of Chronobiology of Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianji","family":"Liao","sequence":"additional","affiliation":[{"name":"Division of Reproductive Medicine West\u00a0China Second University Hospital of Sichuan University  Chengdu China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiying","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Reproductive Medicine West\u00a0China Second University Hospital of Sichuan University  Chengdu China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education  Chengdu China"},{"name":"NHC Key Laboratory of Chronobiology of Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huili","family":"Zhu","sequence":"additional","affiliation":[{"name":"Division of Reproductive Medicine West\u00a0China Second University Hospital of Sichuan University  Chengdu China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education  Chengdu 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