{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:25:24Z","timestamp":1772990724199,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate whether treatment with erythropoiesis\u2010stimulating agents (ESAs) for chemotherapy\u2010induced anemia affects progression\u2010free survival (PFS) in patients receiving front\u2010line chemotherapy following surgery for ovarian cancer (OC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed all consecutive patients who received front\u2010line chemotherapy after surgery between 2013 and 2019 at six institutions. The patients were divided according to the use of ESAs during front\u2010line chemotherapy. The primary endpoint was PFS. The secondary endpoint was the occurrence of thromboembolism. Propensity score matching (PSM) analysis was used to compare survival between matched cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 2147 patients (433 receiving ESA and 1714 for no\u2010ESA) were identified, with a median follow\u2010up of 44.0\u2009months. The ESA group showed a significantly higher proportion of stage III\/IV disease (81.8% vs 61.1%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and postoperative gross residual disease (32.3% vs 21.2%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) than the no\u2010ESA group. In the multivariable Cox regression analysis, the use of ESAs did not affect PFS (adjusted hazard ratio, 1.03; 95% confidence interval [CI]: 0.89\u20131.20;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.661). The incidence of thromboembolism was 10.2% in the ESA group and 4.6% in the no\u2010ESA group (adjusted odds ratio, 6.58; 95% CI: 3.26\u201313.28;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). When comparing the well\u2010matched cohorts after PSM, PFS did not differ between the ESA (median PFS 23.5\u2009months) and no\u2010ESA groups (median PFS 22.2\u2009months) (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.540, log\u2010rank test).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The use of ESAs during front\u2010line chemotherapy did not negatively affect PFS in patients with OC after surgery but increased the risk of thromboembolism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.15533","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T05:08:30Z","timestamp":1714367310000},"page":"132-141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic impact of erythropoietin\u2010stimulating agent use during front\u2010line chemotherapy in patients with ovarian cancer: A Korean multicenter cohort study"],"prefix":"10.1002","volume":"167","author":[{"given":"Seung\u2010Hyuk","family":"Shim","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Research Institute of Medical Science Konkuk University School of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun\u2010Jung","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Soonchunhyang University Cheonan Hospital  Cheonan South Chungcheong Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Bi","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Research Institute of Medical Science Konkuk University School of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seungjun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Seung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon\u2010Kyung","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin\u2010Wha","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Asan Medical Center, University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi\u2010Son","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heekyoung","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Jong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeeyeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Gynecologic Cancer Center Ajou University School of Medicine  Suwon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suk\u2010Joon","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Gynecologic Cancer Center Ajou University School of Medicine  Suwon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myong Cheol","family":"Lim","sequence":"additional","affiliation":[{"name":"Center for Gynecologic Cancer and Center for Clinical Trial, National Cancer Center  Goyang Korea"},{"name":"Division of Tumor Immunology Research Institute and Hospital, National Cancer Center  Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chel 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