{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:59:10Z","timestamp":1792511950079,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271711"],"award-info":[{"award-number":["82271711"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2024,10]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n \n To evaluate non\u2010invasive prenatal testing (NIPT) and expanded non\u2010invasive prenatal testing (NIPT\u2010plus) for detecting aneuploidies at different sequencing depths and assess\n Z<\/jats:italic>\n \u2010score accuracy in predicting trisomies 21, 18, 13, 45X, and 47XXX.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Pregnancies with positive NIPT or NIPT\u2010plus results detected at the prenatal diagnosis center of Nanfang Hospital were included in this retrospective study, between January 2017 and December 2022. Invasive prenatal diagnostic results were collected. Logistic regression analyses were used to study the relationship between\n Z<\/jats:italic>\n \u2010score and positive predictive value (PPV). Optimal cut\u2010off values were obtained based on receiver operating characteristic analysis, and PPVs were calculated in different groups.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We evaluated 1348 pregnant women with positive results, including 930 reported by NIPT and 418 reported by NIPT\u2010plus. NIPT reported significantly more rare chromosomal aneuploidies (RCAs), and NIPT\u2010plus had a significantly higher PPV for trisomy 21 (T21). Logistic regression analyses showed a significant association (\n P<\/jats:italic>\n \u2009<\u20090.001) between\n Z<\/jats:italic>\n \u2010score and PPVs for T21 and trisomy 18 (T18). A linear relationship was observed between fetal fraction (FF) and\n Z<\/jats:italic>\n \u2010values in the true positive cases of T21 and T18.The high\n Z<\/jats:italic>\n \u2010score group had significantly higher PPVs than the low\n Z<\/jats:italic>\n \u2010score group for T21, T18, trisomy 13, and 47XXX, but not for 45X.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The\n Z<\/jats:italic>\n \u2010score is helpful in assessing NIPT or NIPT\u2010plus results. Therefore, we suggest including the\n Z<\/jats:italic>\n \u2010score and FF in the results. By combining the\n Z<\/jats:italic>\n \u2010score, FF, and maternal age, clinicians can interpret NIPT results more accurately and improve personal counsel to reduce patients' anxiety.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ijgo.15535","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T03:44:16Z","timestamp":1713843856000},"page":"273-280","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of the performance of\n NIPT<\/scp>\n and\n NIPT<\/scp>\n \u2010plus for fetal chromosomal aneuploidy and high\n Z<\/i>\n \u2010score increases the positive predictive value"],"prefix":"10.1002","volume":"167","author":[{"given":"Siping","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Nanfang Hospital Southern Medical University Guangzhou 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