{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:58:29Z","timestamp":1787313509179,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004920","name":"Royan Institute","doi-asserted-by":"publisher","award":["98000173"],"award-info":[{"award-number":["98000173"]}],"id":[{"id":"10.13039\/501100004920","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Apolipoprotein E (APOE) is the most important precursor for the production of steroid hormones and is also involved in regulating the function of steroid hormones, hence playing a significant role in reproductive processes. So,\n                      <jats:italic>APOE<\/jats:italic>\n                      gene expression may be correlated with the implantation process. This study tries to make a better clarification of the correlation between\n                      <jats:italic>APOE<\/jats:italic>\n                      gene polymorphisms and recurrent implantation failure (RIF), where we compared the frequency of\n                      <jats:italic>APOE<\/jats:italic>\n                      polymorphisms in RIF patients, assisted reproductive treatment (ART) success cases and fertile women.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      In all, 100 women with successful ART who got pregnant (fetal heart rate positive) in their first or second cycle of in\u00a0vitro fertilization or intracytoplasmic sperm injection, 100 infertile RIF cases, and 100 normal fertile control cases with at least one live birth were included in present study. Following DNA extraction, genotypes were determined through polymerase chain reaction\u2013restriction fragment length polymorphism method using\n                      <jats:italic>Hha<\/jats:italic>\n                      I restriction enzyme. Finally, statistical analysis was performed by chi\u2010squared (\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      ) test in SPSS software (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The RIF group showed significantly higher frequency for E3\/E4 genotype (29%) compared with the other two control groups (fertile\u2009=\u200915%, ART success [ART+]\u2009=\u200913%) (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.007). There was also a significantly higher frequency of the E4 allele in the RIF group (14.5%) compared with both of the control groups (fertile\u2009=\u20097.5%, ART+\u2009=\u20096.5%) (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.018).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>APOE4<\/jats:italic>\n                      is correlated with recurrent failure in the process of embryo implantation and, accordingly, it may potentially be considered a possible risk factor to the implantation process. The presence of E4 can be proposed as a predictive indicator in determining the results of assisted reproductive techniques.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.15537","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T09:30:04Z","timestamp":1713173404000},"page":"169-176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<i>APOE\u2010E4<\/i>\n                    allele as a potential marker for implantation failure: A comparison between fertile women, ART success and RIF patients"],"prefix":"10.1002","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7005-8075","authenticated-orcid":false,"given":"Nazanin","family":"Darabi","sequence":"first","affiliation":[{"name":"Department of Molecular Cell Biology\u2010Genetics, Faculty of Basic Sciences and Advanced Technologies in Biology University of Science and Culture, ACECR  Tehran Iran"},{"name":"Department of Genetics, Reproductive Biomedicine Research Center Royan Institute for Reproductive Biomedicine, ACECR  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2166-3295","authenticated-orcid":false,"given":"Mehri","family":"Mashayekhy","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center Royan Institute for Reproductive Biomedicine, ACECR  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2215-2967","authenticated-orcid":false,"given":"Parnaz","family":"Borjian\u00a0Boroujeni","sequence":"additional","affiliation":[{"name":"Department of Genetics, Reproductive Biomedicine Research Center Royan Institute for Reproductive Biomedicine, ACECR  Tehran 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