{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T17:06:21Z","timestamp":1788800781566,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the age\u2010specific cumulative live birth rates (CLBRs) in intrauterine insemination (IUI) cycles using either donor or husband sperm, and to investigate the impact of sperm sources on IUI success among women within the same age group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study comprised women who underwent IUI with donor sperm (IUI\u2010D) or husband sperm (IUI\u2010H) from 2017 to 2021. The women were stratified based on their age at the initiation of insemination into four categories: &lt;35, 35\u201337, 38\u201339 and \u226540\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 5253 women undergoing 10\u2009415 insemination cycles (3354 with IUI\u2010D and 7061 with IUI\u2010H) were included. The CLBRs decreased significantly with increasing maternal age within donor and husband insemination groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). In the IUI\u2010D group, the crude CLBRs were 61.50% in women aged &lt;35, 48.91% in 35\u201337, 24.14% in 38\u201339 and 11.76% in the \u226540\u2010year age category, respectively. The corresponding rates in the IUI\u2010H group were 27.62%, 22.96%, 13.73% and 6.90%, respectively. Within the &lt;35 and 35\u201337\u2010year age categories, the CLBRs were significantly higher following IUI\u2010D cycles compared to IUI\u2010H cycles, with hazard ratios (HR) of 1.85 (1.68\u20132.04) and 1.69 (1.16\u20132.47), respectively. However, within the 38\u201339 and \u226540\u2010year age categories, both IUI\u2010D and IUI\u2010H resulted in comparable low CLBRs, with HRs of 1.91 (0.77\u20134.76) and 1.80 (0.33\u20139.86), respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Advanced maternal age affects the whole process of fertility. Therefore, it could be reasonable to limit the number of IUI performed in women aged 40\u2009years and older, even in couple using donor sperm for reproduction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.15539","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T06:38:42Z","timestamp":1713249522000},"page":"142-153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cumulative live birth rates following intrauterine insemination using donor and husband sperm in different age groups: A\u00a0cohort study of 10\u2009415 insemination cycles"],"prefix":"10.1002","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7643-4124","authenticated-orcid":false,"given":"Dian","family":"Zhang","sequence":"first","affiliation":[{"name":"Assisted Reproduction Center Northwest Women's and Children's Hospital  Xi'an China"},{"name":"Graduate Department Xi'an Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0890-8913","authenticated-orcid":false,"given":"He","family":"Cai","sequence":"additional","affiliation":[{"name":"Assisted Reproduction Center Northwest Women's and Children's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlin","family":"Xie","sequence":"additional","affiliation":[{"name":"Assisted Reproduction Center Northwest Women's and Children's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Assisted Reproduction Center Northwest Women's and Children's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Zhang","sequence":"additional","affiliation":[{"name":"Assisted Reproduction Center Northwest Women's and Children's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanzi","family":"Shi","sequence":"additional","affiliation":[{"name":"Assisted Reproduction Center Northwest Women's and Children's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.10.014"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32406-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2020.08.010"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.03.012"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.9.2320"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/19396368.2011.603792"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deab148"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13694"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-020-01976-3"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13641"},{"key":"e_1_2_9_12_1","volume-title":"WHO Laboratory Manual for the Examination and Processing of Human Semen","author":"World Health Organization","year":"2010"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2017.01.016"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-021-04342-y"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev336"},{"key":"e_1_2_9_16_1","first-page":"229","article-title":"Reproductive outcomes of women aged 40 and older undergoing IVF with donor sperm","volume":"36","author":"Bortoletto P","year":"2021","journal-title":"Hum Reprod"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dez179"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xfre.2021.04.007"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.01.033"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmx041"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)01641-1"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-022-02551-8"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den008"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex096"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep085"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S106258"}],"container-title":["International Journal of Gynecology &amp; 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