{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:58:26Z","timestamp":1784890706848,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The present study aimed to evaluate low\u2010dose oral misoprostol induction, and compare different methods used in second\u2010line induction in patients with a Bishop score less than 6.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study analyzed the medical history and courses of pregnancy of all patients induced with first\u2010line of low\u2010dose oral misoprostol (50\u2009\u03bcg every 4\u2009h with a total of 200\u2009\u03bcg\/24\u2009h) from April 2021 to June 2022 in a university hospital center, and reported outcomes according to the second\u2010line method of induction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 437 labor inductions with low\u2010dose oral misoprostol, 120 patients required a second\u2010line induction. Predictive factors of first\u2010line failure were higher body mass index (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.011), absence of premature rupture of membranes (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.021) and earlier term of pregnancy (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Regarding second methods of induction of labor, time from induction to delivery was shorter in the oxytocin group than the dinoprostone and misoprostol groups (24.0 vs. 41 and 51.0\u2009h, respectively;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), and was also significantly shorter in the dinoprostone than the misoprostol group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.048). Cesarean section rates did not differ between the three groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.651). There were no clinically significant differences in adverse events between the groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Normal body mass index, previous rupture of membranes and later term of induction of labor were the three favoring success factors during first\u2010line oral misoprostol. In cases of a Bishop score &lt;6, oxytocin may be the best option to reduce duration to delivery, with the same maternal\u2010fetal outcomes, including a similar rate of vaginal delivery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.15552","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T05:03:14Z","timestamp":1713934994000},"page":"313-321","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparative study of second\u2010line labor induction methods in patients with unfavorable cervix after first\u2010line low\u2010dose oral misoprostol"],"prefix":"10.1002","volume":"167","author":[{"given":"Marie\u2010C\u00e9cile","family":"Nace","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Reproduction and Fetal Medicine CHU de Nice, University of C\u00f4te d'Azur  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Delotte","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Reproduction and Fetal Medicine CHU de Nice, University of C\u00f4te d'Azur  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5664-4337","authenticated-orcid":false,"given":"Pierre\u2010Alexis","family":"Gauci","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Reproduction and Fetal Medicine CHU de Nice, University of C\u00f4te d'Azur  Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-020-03137-x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000428648.75548.00"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta20650"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-012-2341-3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD014484"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181945859"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2020.04.004"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)02082-7"},{"key":"e_1_2_10_10_1","unstructured":"Sant\u00e9 publique France partenaire de la 6\u00e8me \u00e9dition de l'Enqu\u00eate Nationale P\u00e9rinatale. n.d. 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