{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:35:44Z","timestamp":1790757344727,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the systemic immune\u2010inflammation index (SII) and neutrophil\u2010to\u2010lymphocyte ratio (NLR) in predicting a successful methotrexate response in tubal ectopic pregnancy (TEP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Women treated for TEP at a tertiary hospital between 2017 and 2021 were retrospectively reviewed. A total of 502 (100%) eligible patients who received methotrexate were included and divided into two groups based on whether or not they were successfully treated with methotrexate alone. Inflammatory parameters derived from the patients' hemograms at hospital admission were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 434 (86.4%) patients were successfully treated with methotrexate alone (Group 1), while 68 (13.6%) patients underwent surgery after methotrexate failure (Group 2). Median neutrophil count, NLR, platelet\u2010to\u2010lymphocyte ratio, monocyte\u2010to\u2010lymphocyte ratio, SII, largest ectopic mass diameter, and \u03b2\u2010human chorionic gonadotropin (\u03b2\u2010hCG) were significantly lower, whereas median lymphocyte and platelet counts were significantly higher in Group 1. According to the receiver operating characteristic analysis performed for the discriminatory power of NLR, \u03b2\u2010hCG, and SII for methotrexate response, the area under the curve values were 0.742, 0.730, and 0.699, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Low NLR and SII are associated with methotrexate success and could be used to refine decision making regarding \u03b2\u2010hCG for predicting successful response to methotrexate in patients with TEP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.15696","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T01:18:30Z","timestamp":1716340710000},"page":"789-796","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The importance of blood\u2010count\u2010derived inflammatory markers in predicting methotrexate success in patients with tubal ectopic pregnancy"],"prefix":"10.1002","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9602-9099","authenticated-orcid":false,"given":"Murat Levent","family":"Dereli","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Ankara Etlik Lady Z\u00fcbeyde Maternity and Women's Health Teaching and Research Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3429-3879","authenticated-orcid":false,"given":"Belgin","family":"Savran \u00dc\u00e7ok","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ankara Etlik Lady Z\u00fcbeyde Maternity and Women's Health Teaching and Research Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2432-1434","authenticated-orcid":false,"given":"Sadullah","family":"\u00d6zkan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ankara Etlik Lady Z\u00fcbeyde Maternity and Women's Health Teaching and Research Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3758-0136","authenticated-orcid":false,"given":"Sadun","family":"Sucu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ankara Etlik Lady Z\u00fcbeyde Maternity and Women's Health Teaching and Research Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9187-2941","authenticated-orcid":false,"given":"Serap","family":"Topkara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ankara Etlik City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4499-3492","authenticated-orcid":false,"given":"Fahri Bur\u00e7in","family":"F\u0131ratl\u0131gil","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ankara Etlik Lady Z\u00fcbeyde Maternity and Women's Health Teaching and Research Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0770-3334","authenticated-orcid":false,"given":"Emel Ebru","family":"Ercan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ankara Etlik Lady Z\u00fcbeyde Maternity and Women's Health Teaching and Research Hospital  Ankara 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