{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T18:43:25Z","timestamp":1774032205129,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the association of first\u2010trimester uterine artery Doppler with hypertensive disorders of pregnancy in twin pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cohort study of twin pregnancies followed at the University Hospital Center of Central Lisbon, Portugal, between January 2010 and December 2022. First\u2010trimester uterine artery pulsatility index (UtA\u2010PI) was determined and compared between twin pregnancies (<jats:italic>n<\/jats:italic>\u2009=\u2009454) and singleton pregnancies (<jats:italic>n<\/jats:italic>\u2009=\u2009908), matched to maternal and pregnancy characteristics. Maternal characteristics and mean UtA\u2010PI were analyzed for gestational age, birth weight, gestational hypertension, early\u2010 and late\u2010onset pre\u2010eclampsia, HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome, and preterm birth. Univariable and multivariable logistic regression models were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean first\u2010trimester UtA\u2010PI was significantly lower in dichorionic twins than in singletons (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). To study hypertensive disorders of pregnancy in twins, 390 pregnancies were included: 311 (79.7%) dichorionic and 79 (20.3%) monochorionic twins. The observed rates of early\u2010 and late\u2010onset pre\u2010eclampsia, gestational hypertension, and HELLP syndrome were 1.0%, 4.4%, 7.4%, and 1.5%, respectively. We achieved a 100% detection rate for early\u2010onset pre\u2010eclampsia using the UtA\u2010PI 90th centile for twins. However, when singleton references were considered, the detection rate decreased to 50%. UtA\u2010PI at or above the 95th centile was associated with increased odds for preterm birth before 32\u2009weeks (adjusted odds ratio 4.1, 95% confidence interval 1.0\u201316.7, <jats:italic>P<\/jats:italic>\u2009=\u20090.043).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Unless other major risk factors for hypertensive disorders are present, women with low UtA\u2010PI will probably not benefit from aspirin prophylaxis. Close monitoring of all twin pregnancies for hypertensive disorders is still recommended.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15706","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T04:44:07Z","timestamp":1716785047000},"page":"705-713","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["First\u2010trimester uterine artery Doppler and hypertensive disorders in twin pregnancies: Use of twin versus singleton references"],"prefix":"10.1002","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1736-1825","authenticated-orcid":false,"given":"Alexandra","family":"Queir\u00f3s","sequence":"first","affiliation":[{"name":"Fetal Medicine and Surgery Center University Hospital Center of Central Lisbon, Centro Cl\u00ednico Acad\u00e9mico de Lisboa  Lisbon Portugal"},{"name":"Maternal and Fetal Medicine Unit University Hospital Center of Central Lisbon, Centro Cl\u00ednico Acad\u00e9mico de Lisboa  Lisbon Portugal"},{"name":"Nova Medical School Nova University Lisbon  Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Domingues","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Unit Setubal Hospital Center  Setubal Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Gomes","sequence":"additional","affiliation":[{"name":"Maternal and Fetal Medicine Unit University Hospital Center of Central Lisbon, Centro Cl\u00ednico Acad\u00e9mico de Lisboa  Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u00eas","family":"Pereira","sequence":"additional","affiliation":[{"name":"Maternal and Fetal Medicine Unit University Hospital Center of Central Lisbon, Centro Cl\u00ednico Acad\u00e9mico de Lisboa  Lisbon 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