{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:48:11Z","timestamp":1765547291934,"version":"3.44.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860587"],"award-info":[{"award-number":["81860587"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012543","name":"Youth Science Foundation of Guangxi Medical University","doi-asserted-by":"publisher","award":["GXMUYSF202203"],"award-info":[{"award-number":["GXMUYSF202203"]}],"id":[{"id":"10.13039\/501100012543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the relationship between maternal blood pressure (BP) and neonatal cord blood telomere length (TL) during pregnancy, and to clarify the sensitive period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a prospective cohort study with 621 mother\u2010newborn pairs from the Guangxi Zhuang Birth Cohort (GZBC) in China. Multiple informant models, restricted cubic spline regression (RCS) models, and quantile regression models were conducted to analyze the correlation between maternal BP and neonatal TL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Maternal diastolic blood pressure (DBP) was inversely related to neonatal cord blood TL in the second trimester (<jats:italic>P<\/jats:italic>\u2009=\u20090.015) and the third trimester (<jats:italic>P<\/jats:italic>\u2009=\u20090.011). There was a male\u2010specific relationship between maternal BP and neonatal TL. A 1\u2009mmHg increment in maternal systolic blood pressure (SBP) and DBP during the second trimester was related with 0.42% (95% CI: \u22120.80%, \u22120.04%) and 0.61% (95% CI: \u22121.13%, \u22120.09%) shorter TL in male newborns, respectively. Per unit increase of maternal DBP during the third trimester was related with 0.54% (95% CI: \u22121.03%, \u22120.05%) shorter TL in male newborns. Pregnant women with hypertensive disease of pregnancy (HDP) had male offspring with shorter TL (<jats:italic>P<\/jats:italic>\u2009=\u20090.003). However, no significant relationships were found in female newborns (<jats:italic>P<\/jats:italic>\u2009=\u20090.570).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maternal BP during pregnancy is inversely correlated with male neonatal TL and the second and third trimesters are sensitive windows.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15721","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T09:24:18Z","timestamp":1718875458000},"page":"765-772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Sex\u2010specific effects of maternal blood pressure on newborn telomere length: A prospective study"],"prefix":"10.1002","volume":"167","author":[{"given":"Yonghong","family":"Sheng","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Health Statistics School of Public Health, Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics School of Public Health, Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siqian","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics School of Public Health, Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yantao","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics School of Public Health, Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqiang","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics School of Public Health, Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Health &amp; Maternal and Child Health School of Public Health, Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongping","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Sanitary Chemistry School of Public Health, Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongxiang","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics School of Public Health, Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics School of Public Health, Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer Tan Hui","family":"Juan","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0671-2597","authenticated-orcid":false,"given":"Xiaoyun","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics School of Public Health, Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab3389"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","DOI":"10.3390\/cells8020107","article-title":"Revisiting telomere shortening in cancer","volume":"8","author":"Okamoto K","year":"2019","journal-title":"Cells"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-017-0964-8"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.19101003"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/mcn.12475"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.153519"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-020-01070-0"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000208"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2017.09.003"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.12.050"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-3093"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2019.03.003"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2020.126422"},{"key":"e_1_2_10_15_1","first-page":"721","article-title":"Diagnosis and treatment guideline of hypertensive disorders in pregnancy (2015)","volume":"50","year":"2015","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.10.e47"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.14509"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-019-00069-6"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/10641955.2020.1742350"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-021-03599-7"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.46234\/ccdcw2021.122"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2017.0310"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-57050-1"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes12010078"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glz240"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2021.08.013"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)06297-6"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.106202"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep07869"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2018.05.025"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.21317"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0261013"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2017.11.008"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2010.09.005"}],"container-title":["International Journal of Gynecology &amp; 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