{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:57:33Z","timestamp":1788872253966,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the accuracy of combined models of maternal biophysical factors, ultrasound, and biochemical markers for predicting stillbirths.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study of pregnant women undergoing first\u2010trimester pre\u2010eclampsia screening at 11\u201313 gestational weeks was conducted. Maternal characteristics and history, mean arterial pressure (MAP) measurement, uterine artery pulsatility index (UtA\u2010PI) ultrasound, maternal ophthalmic peak ratio Doppler, and placental growth factor (PlGF) serum were collected during the visit. Stillbirth was classified as placental dysfunction\u2010related when it occurred with pre\u2010eclampsia or birth weight &lt;10th percentile. Combined prediction models were developed from significant variables in stillbirths, placental dysfunction\u2010related, and controls. We used the area under the receiver\u2010operating\u2010characteristics curve (AUC), sensitivity, and specificity based on a specific cutoff to evaluate the model's predictive performance by measuring the capacity to distinguish between stillbirths and live births.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 13 (0.79%) cases of stillbirth in 1643 women included in the analysis. The combination of maternal factors, MAP, UtA\u2010PI, and PlGF, significantly contributed to the prediction of stillbirth. This model was a good predictor for all (including controls) types of stillbirth (AUC 0.879, 95% CI: 0.799\u20130.959, sensitivity of 99.3%, specificity of 38.5%), and an excellent predictor for placental dysfunction\u2010related stillbirth (AUC 0.984, 95% CI: 0.960\u20131.000, sensitivity of 98.5, specificity of 85.7).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Screening at 11\u201313\u2009weeks' gestation by combining maternal factors, MAP, UtA\u2010PI, and PlGF, can predict a high proportion of stillbirths. Our model has good accuracy for predicting stillbirths, predominantly placental dysfunction\u2010related stillbirths.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15755","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T08:09:32Z","timestamp":1720080572000},"page":"1101-1108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A prediction model for stillbirth based on first trimester pre\u2010eclampsia combined screening"],"prefix":"10.1002","volume":"167","author":[{"given":"Adly Nanda","family":"Al\u2010Fattah","sequence":"first","affiliation":[{"name":"Indonesian Prenatal Institute  Jakarta Indonesia"},{"name":"Kosambi Maternal and Child Center  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7521-9221","authenticated-orcid":false,"given":"Muhammad Pradhiki","family":"Mahindra","sequence":"additional","affiliation":[{"name":"Indonesian Prenatal Institute  Jakarta Indonesia"},{"name":"Elizabeth Garrett Anderson Institute for Women's Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirani Ulfa","family":"Yusrika","sequence":"additional","affiliation":[{"name":"Indonesian Prenatal Institute  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Pradhika","family":"Mapindra","sequence":"additional","affiliation":[{"name":"Indonesian Prenatal Institute  Jakarta Indonesia"},{"name":"Elizabeth Garrett Anderson Institute for Women's Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinda","family":"Marizni","sequence":"additional","affiliation":[{"name":"Indonesian Prenatal Institute  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vania Permata","family":"Putri","sequence":"additional","affiliation":[{"name":"Indonesian Prenatal Institute  Jakarta Indonesia"},{"name":"Kosambi Maternal and Child Center  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadina Pramuktini","family":"Besar","sequence":"additional","affiliation":[{"name":"Harapan Kita National Women and Children's Hospital  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix Firyanto","family":"Widjaja","sequence":"additional","affiliation":[{"name":"Indonesian Prenatal Institute  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raden Aditya","family":"Kusuma","sequence":"additional","affiliation":[{"name":"Indonesian Prenatal Institute  Jakarta Indonesia"},{"name":"Harapan Kita National Women and Children's Hospital  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1078-9856","authenticated-orcid":false,"given":"Dimitrios","family":"Siassakos","sequence":"additional","affiliation":[{"name":"Elizabeth Garrett Anderson Institute for Women's Health University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00837-5"},{"key":"e_1_2_10_3_1","unstructured":"Making every baby count audit and review of stillbirths and neonatal deaths.2016.http:\/\/www.who.int\/about\/"},{"key":"e_1_2_10_4_1","unstructured":"United Nations Inter\u2010agency Group for Child Mortality Estimation YouD HugL MishraA BlencoweH MoranA.A neglected tragedy: the global burden of 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