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Typical prenatal ultrasound characteristics of epignathus include a mixed solid and cystic lesion with vascularity in the solid component, originating from the hard or soft palate, and it is often associated with other anomalies such as craniofacial clefts or trans\u2010sphenoidal intracranial extension. Herein, we present a case of prenatal diagnosis of epignathus with rare ultrasonographic findings, prenatal management requiring collaborative efforts of a multidisciplinary team, and a well\u2010planned innovative ex utero intrapartum treatment procedure. In addition, this report highlights the evolving postnatal diagnosis of the rare developmental anomaly, duplication of the pituitary gland\u2010plus syndrome, which includes various midline craniofacial, central nervous system, spinal, and endocrine abnormalities.<\/jats:p>","DOI":"10.1002\/ijgo.15766","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T09:29:00Z","timestamp":1720171740000},"page":"901-910","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Perinatal management for fetal oral epignathus with <scp>duplication of the pituitary gland (DPG)<\/scp>\u2010plus syndrome: A case report and literature review"],"prefix":"10.1002","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3095-272X","authenticated-orcid":false,"given":"Noppasin","family":"Khwankaew","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Prince of Songkla University  Hat Yai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapphon","family":"Sawaddisan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine Prince of Songkla University  Hat Yai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirikarn","family":"Siripruekpong","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Faculty of Medicine Prince of Songkla University  Hat Yai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peesit","family":"Leelasawatsuk","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine Prince of Songkla University  Hat Yai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manapat","family":"Praditaukrit","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Prince of Songkla University  Hat Yai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pattama","family":"Tanaanantarak","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine Prince of Songkla University  Hat Yai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2019180128"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/JMU.JMU_125_18"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2018.07.003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.04.008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2011.30.4.561"},{"key":"e_1_2_7_7_1","first-page":"168","article-title":"Prenatal diagnosis of a giant epignathus teratoma in the third trimester of pregnancy using three\u2010dimensional ultrasound and magnetic resonance imaging","volume":"16","author":"Santana EF","year":"2014","journal-title":"Case Rep Med Ultrason"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060521996873"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1597\/12-222"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-015-0740-9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.2015.58.1.65"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2001.00456.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001665-200307000-00012"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.20300"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-960682"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-6646(08)60121-7"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000160219"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.20762"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2012.01865.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318242b3f1"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2012.03.027"},{"key":"e_1_2_7_22_1","first-page":"438","article-title":"Epignathus teratoma","volume":"26","author":"Akhtar R","year":"2016","journal-title":"J Coll Physicians Surg Pak"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556131709600106"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-019-04494-1"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.15733"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2015-212416"}],"container-title":["International Journal of Gynecology &amp; 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