{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:39:42Z","timestamp":1790177982120,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,7,7]],"date-time":"2024-07-07T00:00:00Z","timestamp":1720310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016337","name":"Department for the Economy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016337","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>While the pathophysiology of pre\u2010eclampsia has been postulated as being secondary to placental dysfunction, a cardiac origin has more recently been proposed. Although an association between fetal congenital cardiovascular disease and pre\u2010eclampsia has been demonstrated, no precise pathophysiologic mechanism for this association has been described. This review highlights the current biophysical (including echocardiography and Doppler indices) and biochemical (including proteomic, metabolomic and genetic\/transcriptomic) markers of cardiac dysfunction that have been investigated in maternal and fetal cardiac disease and their overlap with predictors of pre\u2010eclampsia. \u00a0 Common pathways of inflammatory and anti\u2010angiogenesis imbalance, endothelial damage, and oxidative stress have been demonstrated in both cardiovascular disease and pre\u2010eclampsia and further investigation into these pathways could help to elucidate the common pathophysiologic mechanisms linking these disorders.<\/jats:p>","DOI":"10.1002\/ijgo.15770","type":"journal-article","created":{"date-parts":[[2024,7,7]],"date-time":"2024-07-07T09:39:11Z","timestamp":1720345151000},"page":"941-948","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Feto\u2010maternal indicators of cardiac dysfunction as a justification for the cardiac origins for pre\u2010eclampsia"],"prefix":"10.1002","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6994-7989","authenticated-orcid":false,"given":"Kelly M.","family":"Reilly","sequence":"first","affiliation":[{"name":"Center for Public Health Queens University Belfast  Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Watson","sequence":"additional","affiliation":[{"name":"Wellcome\u2010Wolfson Institute for Experimental Medicine, Queen's University Belfast  Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Ruddock","sequence":"additional","affiliation":[{"name":"Randox Laboratories Ltd  Antrim UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Watt","sequence":"additional","affiliation":[{"name":"Randox Laboratories Ltd  Antrim UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary 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