{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:02:36Z","timestamp":1787630556147,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971356"],"award-info":[{"award-number":["81971356"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify the vaginal microbial signature in women with chronic endometritis (CE) and investigate the potential of vaginal microbiome characterization as a novel diagnostic tools for CE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study was conducted to compare the characteristics of the vaginal microbiome in 98 women who underwent endometrial biopsy for routine clinical inspection of infertility (49 women diagnosed with CE and 49 with non\u2010CE). The vaginal microbiome was analyzed using 16S ribosomal RNA gene amplicon sequencing. The study included an analysis of diversity, bacterial abundance, and microbial function. In addition, microbial markers were identified, and a CE classifier was developed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The relative abundances of genera, including <jats:italic>Bifidobacterium<\/jats:italic>, <jats:italic>Prevotella<\/jats:italic> and <jats:italic>Gardnerella<\/jats:italic>, were found to be different between the two groups. Analysis of the Kyoto Encyclopedia of Genes and Genomes pathways reported differential expression in metabolism\u2010related pathways in the two groups. We identified four microbial markers of CE (<jats:italic>Enterobacter<\/jats:italic>, <jats:italic>Prevotella<\/jats:italic>, <jats:italic>Faecalibacterium<\/jats:italic>, and <jats:italic>Phascolarctobacterium<\/jats:italic>) and developed a predictive classifier for diagnosing CE, achieving an area under the curve of 83.26%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of the current study revealed that, compared with the non\u2010CE controls, patients with CE have a different vaginal microbiota, highlighting the diagnostic significance of the vaginal microbiome as a promising noninvasive biomarker in detecting CE.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15779","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T14:09:37Z","timestamp":1720620577000},"page":"1034-1042","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Vaginal microbiome dysbiosis as a novel noninvasive biomarker for detection of chronic endometritis in infertile women"],"prefix":"10.1002","volume":"167","author":[{"given":"Yi\u2010ling","family":"Han","sequence":"first","affiliation":[{"name":"Reproductive Medical Center Renmin Hospital of Wuhan University and Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue\u2010yao","family":"Li","sequence":"additional","affiliation":[{"name":"Reproductive Medical Center Renmin Hospital of Wuhan University and Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Reproductive Medical Center Renmin Hospital of Wuhan University and Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo\u2010ni","family":"Xiao","sequence":"additional","affiliation":[{"name":"Reproductive Medical Center Renmin Hospital of Wuhan University and Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Reproductive Medical Center Renmin Hospital of Wuhan University and Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Reproductive Medical Center Renmin Hospital of Wuhan University and Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development  Wuhan 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