{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T09:49:45Z","timestamp":1767865785204,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T00:00:00Z","timestamp":1720742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2700601\u20101"],"award-info":[{"award-number":["2021YFC2700601\u20101"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the optimal endometrial preparation protocol for frozen\u2013thawed embryo transfer (FET) following hysteroscopic polypectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective clinical cohort study involving 464 patients who underwent their first FET after polyp resection between January 2021 and July 2023. The cohorts were categorized into three groups: the natural cycle (NC) group (<jats:italic>n<\/jats:italic>\u2009=\u2009139), the ovarian induction (OI) group (<jats:italic>n<\/jats:italic>\u2009=\u2009117), and the hormone replacement therapy (HRT) group (<jats:italic>n<\/jats:italic>\u2009=\u2009208).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the initial unadjusted analysis, both NC and OI cycles exhibited similar pregnancy rates but were associated with significantly higher implantation rate (56.5%, 57.1% vs 42.0%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), clinical pregnancy rate (73.4%, 74.4% vs 57.2%, <jats:italic>P<\/jats:italic>\u2009=\u20090.001), and ongoing pregnancy rate (OPR; 67.6%, 63.2% vs 51.0%, <jats:italic>P<\/jats:italic>\u2009=\u20090.005) compared to the HRT group. Additionally, the three groups demonstrated comparable abortion rate (7.8%, 14.9% vs 10.9%, <jats:italic>P<\/jats:italic>\u2009=\u20090.299). After adjusting for potential confounders in the multiple logistic regression model, the HRT protocol resulted in a 54% significantly lower OPR compared to the NC protocol (adjusted odds ratio [aOR]\u2009=\u20090.46, 95% confidence interval [CI]: 0.28\u20130.77; <jats:italic>P<\/jats:italic>\u2009=\u20090.003). Meanwhile, the OPR difference between the OI protocol and the NC protocol remained insignificant (OI vs NC: aOR\u2009=\u20090.62, 95% CI: 0.35\u20131.12; <jats:italic>P<\/jats:italic>\u2009=\u20090.112).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The ovulatory\u2010FET scheme (NC and OI) following hysteroscopic polyp resection displayed promising clinical outcomes compared with HRT\u2010FET scheme. The regimen without exogenous estrogen administration should be prioritized for endometrial preparation protocol after polypectomy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15787","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T08:23:58Z","timestamp":1720772638000},"page":"1152-1159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Different endometrial preparation protocols on first frozen\u2013thawed embryo transfer outcomes after hysteroscopic polypectomy: A retrospective cohort study"],"prefix":"10.1002","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1470-1794","authenticated-orcid":false,"given":"Hui","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9295-8037","authenticated-orcid":false,"given":"Chun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7820-9152","authenticated-orcid":false,"given":"Xiu\u2010feng","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2003.00163.x"},{"issue":"7","key":"e_1_2_10_3_1","first-page":"501","article-title":"Routine office hysteroscopy in the investigation of infertile couples before assisted reproduction","volume":"50","author":"C\u00e2ndido dos Reis FJ","year":"2005","journal-title":"J Reprod Med"},{"issue":"2","key":"e_1_2_10_4_1","first-page":"103","article-title":"1000 office\u2010based hysteroscopies prior to in\u00a0vitro fertilization: feasibility and findings","volume":"8","author":"Hinckley MD","year":"2004","journal-title":"JSLS"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2011.09.003"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009461"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.12.034"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.02.008"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.02.016"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(03)00244-6"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.10.2742"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590600585955"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2009.06.011"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh822"},{"issue":"3","key":"e_1_2_10_15_1","first-page":"299","article-title":"Endometrial polyps and their relationship in the pregnancy rates of patients undergoing intrauterine insemination","volume":"39","author":"Kalampokas T","year":"2012","journal-title":"Clin Exp Obstet Gynecol"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/14647273.2020.1855368"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-020-00381-6"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2017.04.025"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199610000-00007"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.08.065"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0530162100"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16777"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-017-1016-1"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-022-02521-0"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-09545-7"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.15787","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T05:34:44Z","timestamp":1731735284000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.15787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,12]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/ijgo.15787"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.15787","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,12]]},"assertion":[{"value":"2024-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}