{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T05:12:13Z","timestamp":1737177133099,"version":"3.33.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7232292"],"award-info":[{"award-number":["7232292"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to illustrate the copper status of diminished ovarian reserve in Chinese women, especially the effects of copper, ceruloplasmin, non\u2010ceruloplasmin\u2010bound copper (NCC) and CuZn superoxide dismutase (SOD1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This case\u2013control, cross\u2010sectional investigation included women with diminished ovarian reserve (DOR group, <jats:italic>n<\/jats:italic>\u2009=\u200935) and matched normal ovarian reserve (NOR group, <jats:italic>n<\/jats:italic>\u2009=\u200935). The serum levels of copper, ceruloplasmin, NCC, SOD1, follicle\u2010stimulating hormone, luteinizing hormone, estradiol, testosterone, and anti\u2010M\u00fcllerian hormone were tested and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The serum copper concentrations (60.88%), NCC (54.75%) and SOD1 (54.75%) in the DOR group were significantly higher than those in the NOR group (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and the concentrations of the three markers were higher in most subgroups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The correlation analysis verified the correlation between copper status and impaired ovarian function. Additionally, linear regression analysis showed that NCC and SOD1 levels were negatively correlated with anti\u2010M\u00fcllerian hormone (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 or 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our exploration found significant increases in copper, NCC and SOD1 levels in DOR and suggests a possible link. Copper status is expected to serve as the predictive marker for DOR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15798","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T11:55:14Z","timestamp":1721994914000},"page":"292-299","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Abnormalities in copper status associated with diminished ovarian reserve: A case\u2013control and cross\u2010sectional study"],"prefix":"10.1002","volume":"168","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4762-828X","authenticated-orcid":false,"given":"Ke","family":"Xu","sequence":"first","affiliation":[{"name":"Dongzhimen Hospital Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyi","family":"Shao","sequence":"additional","affiliation":[{"name":"Dongzhimen Hospital Beijing University of Chinese Medicine  Beijing 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