{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T05:12:28Z","timestamp":1737177148972,"version":"3.33.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this study was to determine the etiologies of recurrent miscarriage in our hospital and whether its diagnostic approach followed the recommendations of the American Society of Reproductive Medicine (ASRM) guidelines published in 2012 and the National Institute for Health and Care Excellence (NICE) guidelines published in 2011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective study. The medical records of 158 patients diagnosed with recurrent miscarriage between 2013 and 2018 at Santander University Hospital were reviewed. The Institutional Review Board of HUS approved the study in May 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most common etiologies identified were protein S deficiency, thrombophilia, and cervical insufficiency, with incidence rates of 25.9%, 10.7%, and 3.8%, respectively. Moreover, the most frequently requested diagnostic tests were for protein S, protein C, and anti\u2010phospholipid IgG. Abnormal results for protein S were obtained in 49% of the patients, whereas lupus anticoagulant was abnormal in 12.8%, and Factor V Leiden gene mutations in 8.5% of the patients. Three substantial deviations from the recommended diagnostic approach for recurrent miscarriage by international guidelines were identified in our population: the lack of request for cytogenetic analysis of pregnancy tissue, request for cytogenetic analysis for the parents in only 0.6% of the study sample, and the request for imaging tests to assess uterine anatomy in only 6.3% of the studied population. Both the ASRM and NICE guidelines were only partially followed with a combined adherence rate of 66.5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The diagnostic approach for recurrent miscarriage poses important clinical challenges when compared to the recommendations of international guidelines. Therefore, the development of a local recurrent miscarriage assessment protocol is proposed in our institution.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.15803","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T09:18:35Z","timestamp":1721726315000},"page":"300-307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Etiology and diagnostic approach of recurrent miscarriage at a reference center in Bucaramanga, Colombia"],"prefix":"10.1002","volume":"168","author":[{"given":"Dalia M.","family":"Corrales","sequence":"first","affiliation":[{"name":"Medicine School, Health Faculty Industrial University of Santander  Bucaramanga Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janer","family":"Sep\u00falveda","sequence":"additional","affiliation":[{"name":"Medicine School, Health Faculty Industrial University of Santander  Bucaramanga Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo A.","family":"Contreras","sequence":"additional","affiliation":[{"name":"Medicine School, Health Faculty Industrial University of Santander  Bucaramanga Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Barajas","sequence":"additional","affiliation":[{"name":"Medicine School, Health Faculty Industrial University of Santander  Bucaramanga Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2346-6455","authenticated-orcid":false,"given":"Mar\u00eda P.","family":"Silva","sequence":"additional","affiliation":[{"name":"Medicine School, Health Faculty Industrial University of Santander  Bucaramanga Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermes","family":"Jaimes","sequence":"additional","affiliation":[{"name":"Medicine School, Health Faculty Industrial University of Santander  Bucaramanga Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,23]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","first-page":"11","article-title":"Genetic regulation of recurrent spontaneous abortion in humans","volume":"38","author":"Vaiman D","year":"2015","journal-title":"Biom J"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.06.005"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.09.023"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17515"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.06.048"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoy004"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoad002"},{"volume-title":"Consenso Latinoamericano de Diabetes y Embarazo","year":"2007","author":"M\u00e1rquez Guill\u00e9n A","key":"e_1_2_11_9_1"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000437739.71477.ee"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogrm.2014.11.004"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0000000000000214"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2012.683083"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2014.10.002"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8229.102316"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S100817"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17187"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.11.003"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.07.1975"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2016.1269317"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1005330"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2013.10.005"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2018.12.008"},{"issue":"2","key":"e_1_2_11_24_1","first-page":"179","article-title":"Management of recurrent pregnancy loss","volume":"78","author":"ACOG practice bulletin","year":"2002","journal-title":"Int J Gynaecol Obstet"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1552586"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0000000000000647"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0412.2010.01000.x"}],"container-title":["International Journal of Gynecology &amp; 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